A surface protein of Streptococcus suis serotype 2 identified by proteomics protects mice against infection

Journal of Proteomics
Francesca MandaniciManuel J Rodríguez-Ortega

Abstract

Streptococcus suis serotype 2 is a major Gram-positive swine pathogen, causing also zoonoses. We describe here the immunoprotective activity in an in vivo animal model of a serotype-2 cell wall protein, designated Sat, which was identified by a previously validated proteomics approach consisting of the protease digestion of live bacteria and the selective recovery of exposed domains, followed by LC/MS/MS analysis. Increased survival rate (80%) and decreased bacterial burden were observed in mice immunized with a recombinant Sat fragment, suggesting that this protein is a potential vaccine candidate against serotype-2 infection.

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Citations

Apr 30, 2013·Journal of Proteomics·Alfonso Olaya-AbrilManuel J Rodríguez-Ortega
Oct 16, 2015·Expert Review of Vaccines·Mariela Segura
Apr 28, 2012·Proteomics·Bernd GesslbauerAndreas J Kungl
Jul 31, 2012·Journal of Proteomics·Lidia Gómez-GascónManuel J Rodríguez-Ortega
Jun 19, 2013·Journal of Proteomics·Salvatore PapasergiConcetta Beninati
Aug 2, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Lidia Gómez-GascónInmaculada Luque
Jul 18, 2015·Molecular & Cellular Proteomics : MCP·Alfonso Olaya-AbrilManuel J Rodríguez-Ortega
Dec 7, 2017·Frontiers in Pharmacology·Zhixin LeiQigai He

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