A Surgical Mouse Model for Advancing Laryngeal Nerve Regeneration Strategies.

Dysphagia
Alexis MokTeresa E Lever

Abstract

Iatrogenic recurrent laryngeal nerve (RLN) injury is a morbid complication of anterior neck surgical procedures. Existing treatments are predominantly symptomatic, ranging from behavioral therapy to a variety of surgical approaches. Though laryngeal reinnervation strategies often provide muscle tone to the paralyzed vocal fold (VF), which may improve outcomes, there is no clinical intervention that reliably restores true physiologic VF movement. Moreover, existing interventions neglect the full cascade of molecular events that affect the entire neuromuscular pathway after RLN injury, including the intrinsic laryngeal muscles, synaptic connections within the central nervous system, and laryngeal nerve anastomoses. Systematic investigations of this pathway are essential to develop better RLN regenerative strategies. Our aim was to develop a translational mouse model for this purpose, which will permit longitudinal investigations of the pathophysiology of iatrogenic RLN injury and potential therapeutic interventions. C57BL/6J mice were divided into four surgical transection groups (unilateral RLN, n = 10; bilateral RLN, n = 2; unilateral SLN, n = 10; bilateral SLN, n = 10) and a sham surgical group (n = 10). Miniaturized transoral...Continue Reading

References

Nov 1, 1979·The Laryngoscope·R L Crumley
Jun 1, 1994·Experimental Neurology·P M BridgeC Hertl
Mar 1, 1994·Journal of Voice : Official Journal of the Voice Foundation·R L Crumley
Oct 23, 1995·Brain Research·E VerdúX Navarro
Jan 1, 1996·Dysphagia·J C RosenbekJ L Wood
Mar 29, 2000·The Anatomical Record·L Mu, I Sanders
Apr 25, 2000·The Annals of Otology, Rhinology, and Laryngology·R L Crumley
Feb 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Q Sang, R K Goyal
Feb 5, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Wai-Mun YueThomas R Highland
Jul 12, 2005·Muscle & Nerve·Paul J KinghamGiorgio Terenghi
Nov 4, 2005·Cleveland Clinic Journal of Medicine·Mark S Baron
Oct 4, 2006·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·A M KellyM J Drinnan
Feb 20, 2007·The Annals of Otology, Rhinology, and Laryngology·Gayle E Woodson
Jan 15, 2008·Journal of Voice : Official Journal of the Voice Foundation·Liancai Mu, Ira Sanders
Jul 1, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Laura E T HetzlerEileen M Foecking
Sep 23, 2008·Journal of Speech, Language, and Hearing Research : JSLHR·Lisa B ThomasFrancisco H Andrade
Dec 25, 2008·Dysphagia·Teresa E LeverAlexander K Murashov
Jun 6, 2009·Dysphagia·Teresa E LeverAlexander K Murashov
Jul 3, 2009·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·L Mu, I Sanders
Aug 18, 2009·International Review of Neurobiology·Uros KovacicFajko F Bajrović
Mar 11, 2010·Spine·Satyajit MarawarStavros G Memtsoudis
Jun 19, 2010·Journal of Oral Rehabilitation·H ToharaH Uematsu
Jul 20, 2010·The Laryngoscope·Nijee SharmaEileen M Foecking
Oct 13, 2010·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Elke BrunnerMarkus Gugatschka
May 21, 2011·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J A Logemann, K Larsen
Jun 17, 2011·The Annals of Otology, Rhinology, and Laryngology·Matthew O OldNorman D Hogikyan
Nov 30, 2011·Surgical and Radiologic Anatomy : SRA·Wen-Jing TangHai-Xia Huang
Jul 10, 2012·Journal of Rehabilitation Research and Development·Eileen M FoeckingKathryn J Jones
Nov 8, 2012·The Annals of Otology, Rhinology, and Laryngology·Gunnar BjörckJonas Hydman
Mar 1, 2013·Journal of Anatomy·Ignacio Hernández-MoratoArán Pascual-Font
Apr 5, 2013·Frontiers in Physiology·Di Wu, Alexander K Murashov
Jun 14, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sujana S ChandrasekharUNKNOWN American Academy of Otolaryngology-Head and Neck Surgery
Jul 3, 2013·The Laryngoscope·Robbi A KupferNorman D Hogikyan
Aug 2, 2013·Restorative Neurology and Neuroscience·Gina N MonacoEileen M Foecking
Sep 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Jeong-Seok ChoiJae-Yol Lim
Jan 18, 2014·Global Spine Journal·Karen K Anderson, Paul M Arnold
Feb 21, 2014·Journal of the National Cancer Institute·Louise A BrintonDavid B Thomas
Oct 7, 2014·The Laryngoscope·Randal C PanielloNick L Debnath

❮ Previous
Next ❯

Citations

Feb 23, 2020·Frontiers in Neurology·Lauren WelbyTeresa E Lever
Feb 26, 2020·The Laryngoscope·Lauren WelbyTeresa E Lever
Mar 28, 2020·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Ashley KloepperTeresa E Lever

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.