A survey comparing lamotrigine and vigabatrin in everyday clinical practice

Seizure : the Journal of the British Epilepsy Association
G Schapel, D Chadwick

Abstract

The objective of this study was to compare the efficacy and tolerability of two new antiepileptic drugs, lamotrigine (LTG) and vigabatrin (GVG) in everyday clinical practice. A comprehensive retrospective survey of a computerized data base and hospital case notes was carried out at the Mersey Regional Epilepsy Clinic (MREC), Liverpool, which services a population of 3 million in the North West of England. The study comprised 333 out-patients with refractory epilepsy exposed to LTG and GVG forming a subset in a total population of 2250 patients with epilepsy held on a comprehensive database. The main outcome measures were duration of treatment with each drug described by a Kaplan-Meier survival curve, seizure control determined by a 50% decrease in seizure frequency and freedom from seizures, and incidence of adverse drug effects leading to discontinuation. The Kaplan-Meier curve indicated a 57% probability of patients continuing to take LTG and 43% GVG after 40 months. A 50% improvement in seizure control followed the addition of LTG in 45% of patients, with 10% seizure free, compared with 32% and 6%, respectively after the addition of GVG. LTG was discontinued because of adverse events (most frequently skin rash) in 15% of pat...Continue Reading

Citations

Jan 17, 2004·Epilepsy & Behavior : E&B·Rianne ReijsMarc De Krom
Apr 8, 1998·Seizure : the Journal of the British Epilepsy Association·G J SchapelG S Gordon
May 30, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E BonanniL Murri
Mar 1, 2003·Epilepsy & Behavior : E&B·Daniel Y.C. WangAaron Fix
Feb 20, 2002·British Journal of Clinical Pharmacology·John S Duncan
May 18, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M W KellettD W Chadwick
Apr 24, 2014·Current Treatment Options in Neurology·Batool F KirmaniDaniel Cruz
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H StefanO Steinlein
Feb 11, 2000·Seizure : the Journal of the British Epilepsy Association·P K Datta, P M Crawford

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