PMID: 9530945Apr 8, 1998Paper

A survey of lamotrigine and vigabatrin treatment in children with severe epilepsy

Seizure : the Journal of the British Epilepsy Association
G J SchapelG S Gordon

Abstract

A retrospective survey was carried out of add-on treatment with lamotrigine (LTG) and vigabatrin (GVG) in 109 children with severe epilepsy, treated between 1987 and 1994, identified from a total population of 300 patients seen annually, in a tertiary referral outpatient clinic in Cardiff, Wales. Of 79 patient treatments with LTG and 86 with GVG, 42 patients were treated with add-on LTG, 52 with add-on GVG and 20 with both drugs simultaneously. A Kaplan-Meier curve, applied to each of the two index drugs, indicated that 71 and 62% of patients would be expected to continue taking LTG or GVG, respectively after 40 months. Improved seizure control (> or = 50%) at the time of audit was seen in 65% of LTG and 58% of GVG patient treatments for all epilepsy syndromes, but there was a higher proportion of patients with generalized epilepsy improved by LTG (28/41, 68%) than that improved by GVG (8/20, 40%), and only those with generalized epilepsy treated with LTG became seizure free (8/38, 21%). Similar proportions of patients discontinued LTG (16%) and GVG (15%) due to an adverse experience, but a higher proportion discontinued GVG (18%) compared with LTG (6%) because of lack of efficacy. This study supports the relative clinical effe...Continue Reading

References

Jan 1, 1991·Journal of Child Neurology·C ChironJ Mumford
Jan 1, 1989·British Journal of Clinical Pharmacology·J H LivingstonJ Aicardi
Mar 1, 1995·Seizure : the Journal of the British Epilepsy Association·R E Appleton
Dec 1, 1995·The Journal of Pediatrics·F M BesagG Hosking
Dec 1, 1996·Seizure : the Journal of the British Epilepsy Association·G Schapel, D Chadwick
Jun 1, 2007·Journal of Clinical Neurology·Dong-Gun KimOk Joon Kim
Mar 1, 1994·CNS Drugs·J T Gilman, M Duchowny

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Citations

Jun 17, 1998·Brain & Development·B F Bourgeois

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