A Survey of Retinal Remodeling

Frontiers in Cellular Neuroscience
Enrica Strettoi

Abstract

Up to 15 years ago, bibliographic searches based on keywords such as "photoreceptor degeneration, inner retina" or "photoreceptor degeneration, second order neurons" returned only a handful of papers, as the field was dominated by the general assumption that retinal degeneration had direct effects on the sole populations of rods and cones. Since then, a number of studies have been dedicated to understanding the process of gradual morphological, molecular, and functional changes arising among cells located in the inner retina (comprising neurons, glia, and blood vessels), that is to say "beyond" photoreceptors. General aspects of this progression of biological rearrangements, now referred to as "remodeling", were revealed and demonstrated to accompany consistently photoreceptor loss, independently from the underlying cause of degeneration. Recurrent features of remodeling are summarized here, to provide a general frame for to the various analytical descriptions and reviews contributed by the articles in the issue (among others, see Euler and Schubert, 2015; Soto and Kerschensteiner, 2015, this issue).

References

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Oct 27, 2015·Frontiers in Cellular Neuroscience·Florentina Soto, Daniel Kerschensteiner
Dec 1, 2015·Frontiers in Cellular Neuroscience·Thomas Euler, Timm Schubert

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Citations

Dec 17, 2016·Current Opinion in Neurology·Michael J Gilhooley, James Acheson
Aug 23, 2017·Journal of Neural Engineering·Priya R Gupta, Rachel M Huckfeldt
May 13, 2018·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Corey M RountreeLaxman Saggere
Dec 18, 2018·Investigative Ophthalmology & Visual Science·Christina SchwarzJennifer J Hunter
Jun 19, 2019·Stem Cells and Development·Ratnesh K SinghIgor O Nasonkin
May 28, 2020·Micromachines·Shinyong ShimSung June Kim
Oct 15, 2019·Frontiers in Neuroscience·Antonio FalasconiEnrica Strettoi
Sep 25, 2019·International Journal of Molecular Sciences·Diego García-AyusoMaría P Villegas-Pérez
May 24, 2017·Annual Review of Vision Science·Gordon E Legge, Susana T L Chung
Sep 15, 2020·Frontiers in Cell and Developmental Biology·Larissa IkelleMuna I Naash

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