A Survey of the Adverse Effects and Influence of Concomitant Drugs for Methotrexate Intrathecal Administration

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Masanobu UchiyamaHidetoshi Kamimura

Abstract

In general, the intraventricular administration of cytotoxic antitumor drugs provides a high drug concentration in the cerebrospinal fluid with a reduced risk of systemic adverse reactions. Methotrexate (MTX) high-dose therapy requires close monitoring when performed in combination with trimethoprim-sulfamethoxazole (ST) therapy and proton pump inhibitor (PPI) and nonsteroidal anti-inflammatory drug administration for excretion delay and toxicity enhancement. While the frequency of systemic side effects is thought to be low with intrathecal administration, such effects do rarely but occasionally occur. We must consider drug interactions with combination therapy as a potential factor inducing such effects. We examined the patients who received MTX intrathecal administration at Fukuoka University Hospital from January 2013 to December 2014 with respect to the onset of side effects and combination therapy. MTX intrathecal administration was performed a total of 79 times in 27 patients. In five of these 27 patients, MTX intrathecal administration was performed twice a week, and hematotoxicity and non-hematotoxicity developed in two patients in whom ST was also administered. On the other hand, even if ST and/or PPI was administered,...Continue Reading

References

Aug 1, 1989·Annals of Internal Medicine·M E JeurissenL B van de Putte
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KantarjianE J Freireich
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HollenderH Holte
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E ZuccaUNKNOWN International Extranodal Lymphoma Study Group
Dec 14, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H-T ArkenauA Horwich
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven H BernsteinRichard I Fisher
Dec 17, 2008·British Journal of Clinical Pharmacology·Kunihiro SuzukiYukinao Kohda
Jan 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Françoise HuguetHervé Dombret
Oct 29, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D VillaK J Savage

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.