PMID: 8449717Apr 1, 1993Paper

A survey of the Czechoslovak follow-up of lung cancer mortality in uranium miners

Health Physics
J SevcA M Kellerer

Abstract

The major Czechoslovak cohort of uranium miners (S-cohort) is surveyed in terms of diagrams illustrating dependences on calendar year, age, and exposure to radon and radon progeny. An analysis of the dose dependence of lung cancer mortality is performed by nonparametric and, subsequently, by parametric methods. In the first step, two-dimensional isotonic regression is employed to derive the lung cancer mortality rate and the relative excess risk as functions of age attained and of lagged cumulated exposure. In a second step, analytical fits in terms of relative risk models are derived. The treatment is largely analogous to the methods applied by the BEIR IV Committee to other major cohorts of uranium miners. There is a marked dependence of the excess risk on age attained and on time since exposure. A specific characteristic of the Czechoslovak data is the nonlinearity of the dependence of the lung cancer excess risk on the cumulated exposure; exposures on the order of 100 working level months or less appear to be more effective per working level month than larger exposures but, in the absence of an internal control group, this cannot be excluded to be due to confounders such as smoking or environmental exposures. A further nota...Continue Reading

Citations

Dec 25, 2002·European Journal of Radiology·C J Beadsmoore, N J Screaton
Jan 28, 2004·Health Physics·Michèle V El MaySadok Mtimet
Nov 24, 2004·Health Physics·Victor E ArcherDae-Yong Hong
May 1, 1994·Occupational and Environmental Medicine·L TomásekE Kunz
Mar 1, 1995·Occupational and Environmental Medicine·M M Finkelstein
Mar 1, 1995·Environmental Health Perspectives·R W HornungR Roscoe
Mar 1, 1995·Environmental Health Perspectives·L Tomásek, S C Darby
Apr 23, 2014·Radiation Protection Dosimetry·L Tomasek
Mar 1, 1995·Radiation and Environmental Biophysics·A M KellererD Barclay
Mar 9, 2006·Radiation and Environmental Biophysics·M Kreisheimer
Dec 1, 1996·International Journal of Radiation Biology·M BauchingerV Georgiadou-Schumacher
Oct 29, 2002·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·L Tomásek

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