A survey of the year 2006 literature on applications of isothermal titration calorimetry

Journal of Molecular Recognition : JMR
Oksana Okhrimenko, Ilian Jelesarov

Abstract

Isothermal titration calorimetry (ITC) is a fast and robust method to determine the energetics of association reactions in solution. The changes in enthalpy, entropy and heat capacity that accompany binding provide unique insights into the balance of forces driving association of molecular entities. ITC is used nowadays on a day-to-day basis in hundreds of laboratories. The method aids projects both in basic and practice-oriented research ranging from medicine and biochemistry to physical chemistry and material sciences. Not surprisingly, the range of studies utilizing ITC data is steadily expanding. In this review, we discuss selected results and ideas that have accumulated in the course of the year 2006, the focus being on biologically relevant systems. Theoretical developments, novel applications and studies that provide a deeper level of understanding of the energetic principles of biological function are primarily considered. Following the appearance of a new generation of titration calorimeters, recent papers provide instructive examples of the synergy between energetic and structural approaches in biomedical and biotechnological research.

References

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Citations

Oct 15, 2013·Journal of Pharmaceutical and Biomedical Analysis·Piotr DraczkowskiKrzysztof Jozwiak
Apr 21, 2011·Journal of Visualized Experiments : JoVE·Lee A FreiburgerKarine Auclair
Aug 30, 2008·Journal of Molecular Recognition : JMR·Sasa Bjelić, Ilian Jelesarov
Jan 4, 2012·Journal of Molecular Recognition : JMR·Rajesh GhaiBrett M Collins
Mar 10, 2010·Journal of Molecular Recognition : JMR·Robert J FalconerBrett M Collins
Dec 26, 2013·Biochimica Et Biophysica Acta·Bing FangFa Zheng Ren
Apr 8, 2011·Journal of Biomolecular Structure & Dynamics·Shagufta H KhanRaj Kumar
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Yi Liang
Nov 25, 2020·Bioorganic & Medicinal Chemistry·Shu-Yu WangSai-Yang Zhang
Oct 21, 2009·The Journal of Physical Chemistry. B·Ger J M KoperErnst J R Sudhölter

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