A survey of the year 2007 literature on applications of isothermal titration calorimetry

Journal of Molecular Recognition : JMR
Sasa Bjelić, I Jelesarov

Abstract

Elucidation of the energetic principles of binding affinity and specificity is a central task in many branches of current sciences: biology, medicine, pharmacology, chemistry, material sciences, etc. In biomedical research, integral approaches combining structural information with in-solution biophysical data have proved to be a powerful way toward understanding the physical basis of vital cellular phenomena. Isothermal titration calorimetry (ITC) is a valuable experimental tool facilitating quantification of the thermodynamic parameters that characterize recognition processes involving biomacromolecules. The method provides access to all relevant thermodynamic information by performing a few experiments. In particular, ITC experiments allow to by-pass tedious and (rarely precise) procedures aimed at determining the changes in enthalpy and entropy upon binding by van't Hoff analysis. Notwithstanding limitations, ITC has now the reputation of being the "gold standard" and ITC data are widely used to validate theoretical predictions of thermodynamic parameters, as well as to benchmark the results of novel binding assays. In this paper, we discuss several publications from 2007 reporting ITC results. The focus is on applications i...Continue Reading

References

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Citations

May 11, 2010·Analytical and Bioanalytical Chemistry·Karine VuignierSophie Martel
Oct 15, 2013·Journal of Pharmaceutical and Biomedical Analysis·Piotr DraczkowskiKrzysztof Jozwiak
Sep 11, 2009·International Journal of Molecular Sciences·Bruno PaganoConcetta Giancola
Apr 21, 2011·Journal of Visualized Experiments : JoVE·Lee A FreiburgerKarine Auclair
Mar 25, 2011·Journal of Pharmacy & Bioallied Sciences·Antonio RaudinoMartina Pannuzzo
Oct 23, 2010·European Journal of Medicinal Chemistry·Juliana CheleskiCarlos A Montanari
Nov 21, 2009·Analytical Biochemistry·Maria João MorenoAdrian Velazquez-Campoy
Jan 4, 2012·Journal of Molecular Recognition : JMR·Rajesh GhaiBrett M Collins
Mar 10, 2010·Journal of Molecular Recognition : JMR·Robert J FalconerBrett M Collins
Dec 16, 2010·Journal of Molecular Recognition : JMR·Robert J Falconer, Brett M Collins
Sep 10, 2015·Acta Biochimica Et Biophysica Sinica·Kejiang LinDonghai Lin
Aug 17, 2011·Biochimica Et Biophysica Acta·Fadi Bou-Abdallah, Tyson R Terpstra
Oct 27, 2009·Chembiochem : a European Journal of Chemical Biology·Lee A FreiburgerAnthony K Mittermaier
Apr 8, 2011·Journal of Biomolecular Structure & Dynamics·Shagufta H KhanRaj Kumar
Feb 18, 2012·Chemistry : a European Journal·Wenbin HuThomas Schrader
Apr 3, 2021·Analytical and Bioanalytical Chemistry·Ghassan Al Hamoui Dit BanniReine Nehmé
Oct 21, 2009·The Journal of Physical Chemistry. B·Ger J M KoperErnst J R Sudhölter
Dec 2, 2010·Biochemistry·Paul DaviesDavid R Brown
Jul 12, 2013·The Journal of Physical Chemistry. B·Isaac Herrera, Mitchell A Winnik
Dec 18, 2013·The Journal of Physical Chemistry. B·Zhihong LiuKlaus Müllen

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