A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population

Nature Genetics
T LaitinenJ Kere

Abstract

The genetics of asthma and atopy have been difficult to determine because these diseases are genetically heterogeneous and modified by environment. The pedigrees in our study (n=86) originate in eastern central Finland (Kainuu province). According to census records, this region had only 200 households (2,000 inhabitants) in the mid sixteenth to mid seventeenth centuries. The current population of 100,000 represents the expansion of these founders within the past 400 years. Because this population is relatively homogeneous, we hypothesized that the molecular genetic mechanisms underlying asthma might also have reduced heterogeneity and therefore be easier to dissect than in mixed populations. A recent twin family study supported a strong genetic component for asthma in Finland. We carried out a genome-wide scan for susceptibility loci in asthma in the Kainuu subpopulation. We identified two regions of suggestive linkage and studied them further with higher-density mapping. We obtained evidence for linkage in a 20-cM region of chromosome 7p14-p15 for three phenotypes: asthma, a high level of immunoglobulin E (IgE; atopy) and the combination of the phenotypes. The strongest linkage was seen for high serum IgE (non-parametric linka...Continue Reading

References

Sep 1, 1990·American Journal of Physical Anthropology·C R GuglielminoL L Cavalli-Sforza
Jun 1, 1987·The Journal of Allergy and Clinical Immunology·R A BarbeeB Burrows
Oct 1, 1993·Journal of Medical Genetics·A de la Chapelle
Aug 1, 1995·Genome Research·A SajantilaS Pääbo
Sep 19, 1996·Nature·S E DanielsW O Cookson
Nov 5, 1997·American Journal of Human Genetics·A Kong, N J Cox
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A F VuorioK Kontula
Jun 13, 1998·American Journal of Human Genetics·L Kruglyak, M J Daly
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·T LaitinenL A Laitinen
Jun 20, 1998·Science·C Zuany-AmorimM Pretolani
Jul 14, 1998·Nature Medicine·T W Mak, D A Ferrick
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·A de la Chapelle, F A Wright

❮ Previous
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Citations

Jul 18, 2002·Allergy·A HaagerupT A Kruse
Jan 14, 2010·European Journal of Human Genetics : EJHG·Emmanuelle BouzigonCathryn M Lewis
May 15, 2004·Nature Reviews. Genetics·Marsha Wills-Karp, Susan L Ewart
Mar 18, 2008·Human Molecular Genetics·Julia H WhiteSreekumar G Pillai
Aug 21, 2010·Current Opinion in Allergy and Clinical Immunology·Kathleen C Barnes
Aug 13, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Juha Kere
Mar 10, 2006·Journal of Medical Genetics·C Brasch-AndersenT A Kruse
Sep 20, 2001·Thorax·T HaahtelaUNKNOWN Working Group of the Asthma Programme in Finland 1994-2004
Nov 10, 2001·Annual Review of Genomics and Human Genetics·J Kere
Aug 16, 2006·Annual Review of Medicine·Yohan Bossé, Thomas J Hudson
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Benjamin A RabyScott T Weiss
Mar 17, 2007·American Journal of Respiratory and Critical Care Medicine·Philippe BéginCatherine Laprise
Jan 12, 2008·American Journal of Respiratory and Critical Care Medicine·Mamta SharmaBalaram Ghosh
Jun 11, 2005·American Journal of Respiratory Cell and Molecular Biology·Johanna VendelinTarja Laitinen
Aug 24, 2005·BMC Genetics·Carolina Perez-IratxetaMiguel A Andrade
Dec 19, 2008·Arthritis Research & Therapy·Rebeccah J MathewsMichael F McDermott
Aug 7, 2008·PloS One·Karine TremblayCatherine Laprise
Apr 6, 2012·PloS One·Thejkiran Pitti, Narayanan Manoj
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·E Noguchi, T Arinami
Dec 21, 2002·Immunological Reviews·William Cookson
Jan 7, 2005·BMC Pulmonary Medicine·Janine AltmüllerMatthias Wjst
Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Gary M HunninghakeJuan C Celedón
Sep 12, 2001·Allergy·S G JohanssonUNKNOWN EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Emiko NoguchiTadao Arinami
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·William G H AbbottColin F Tukuitonga
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E YlikoskiR Lahesmaa
Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham Devereux
Jan 11, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G MalerbaP F Pignatti
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NoguchiT Arinami
Nov 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Takaharu NegoroTakashi Tobe
May 2, 2002·The Journal of Investigative Dermatology·Francesca CaponRichard Trembath
Jul 26, 2006·Journal of Human Genetics·Takeshi AokiEmiko Noguchi
Mar 4, 2008·British Journal of Pharmacology·C SzalaiA Falus
Feb 19, 2005·Human Molecular Genetics·Pirro HysiWilliam O C Cookson
Jul 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C VergaraL Caraballo
Dec 5, 2006·Human Molecular Genetics·Benjamin A RabyJuan C Celedón
Jul 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Irving C AllenBeverly H Koller

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