A suspected case of ornithine transcarbamylase deficiency in a cat

The Journal of Veterinary Medical Science
Tsukimi WashizuTakashi Suzuki

Abstract

An 18 month-old, intact female American Shorthair cat was presented for evaluation of stunted growth and postprandial depression. Fasting serum ammonia and serum bile acid concentrations were above reference ranges at 396 microg/dl and 6.5 micromol/ l and their postprandial concentrations were 785 microg/dl and 9.5 micromol/l, respectively. The initial tentative diagnosis of a portosystemic shunt was excluded by mesenteric portography and histopathology of the liver. The cat was then suspected of a urea cycle enzyme deficiency and its urine was analyzed by gas chromatography-mass spectrometry. A presumptive diagnosis of ornithine transcarbamylase deficiency was made on the basis of the detection of orotic acid and uracil.

References

Apr 1, 1979·The Journal of Pediatrics·D R LaBrecqueG Klatskin
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Jun 10, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·A H Van GennipS K Wadman
Apr 1, 1995·The Journal of Veterinary Medical Science·M MatsumotoI Matsumoto

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Citations

May 20, 2011·Equine Veterinary Journal·B DunkelR Boston
Apr 6, 2007·The Journal of Veterinary Medical Science·Yasunori OhbaHitoshi Kitagawa
Aug 22, 2012·Journal of Feline Medicine and Surgery·Takayuki WatanabeIkuo Sakata
Oct 10, 2020·Journal of Feline Medicine and Surgery·Charlotta H NilssonSofie Ae Van Meervenne
Nov 21, 2020·Journal of Feline Medicine and Surgery·Lauren CarvalhoCynthia Rl Webster

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