A sustained viral response is associated with reduced liver-related morbidity and mortality in patients with hepatitis C virus

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Amit G SingalPhilip S Schoenfeld

Abstract

The incidences of decompensated cirrhosis (defined by ascites, hepatic encephalopathy, or bleeding esophageal varices), hepatocellular carcinoma (HCC), and liver-related mortality among patients infected with hepatitis C virus (HCV) who achieve a sustained viral response (SVR), compared with patients who fail treatment (treatment failure), are unclear. We performed a meta-analysis to quantify the incidences of these outcomes. This meta-analysis included observational cohort studies that followed HCV treatment failure patients; data were collected regarding the incidence of decompensated cirrhosis, HCC, or liver-related mortality and stratified by SVR status. Two investigators independently extracted data on patient populations, study methods, and results by using standardized forms. The agreement between investigators in data extraction was greater than 95%. Data analysis was performed separately for studies that enrolled only HCV patients with advanced fibrosis. We identified 26 appropriate studies for meta-analysis. Among treatment failure patients with advanced fibrosis, rates of liver-related mortality (2.73%/year; 95% confidence interval [CI], 1.38-4.080), HCC (3.22%/year, 95% CI, 2.02-4.42), and hepatic decompensation (2....Continue Reading

Citations

Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Aug 24, 2010·The Journal of Infectious Diseases·Josiah D Rich, Lynn E Taylor
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brian L Pearlman, Nomi Traub
Jun 22, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John W WardHoward K Koh
Dec 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Norbert Bräu
Apr 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Soo AlemanRolf Hultcrantz
May 13, 2010·The Journal of Antimicrobial Chemotherapy·Michael L Volk
Mar 25, 2014·World Journal of Gastroenterology : WJG·Cristiane Valle TovoPaulo Roberto Lerias de Almeida
May 9, 2014·International Journal of Nanomedicine·Chen-Hua Liu, Jia-Horng Kao
May 17, 2014·World Journal of Gastroenterology : WJG·Salman NusratMohammad F Madhoun
May 21, 2014·PloS One·Benjamin P LinasBruce R Schackman
Feb 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lynn E TaylorKaren T Tashima
Feb 11, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dorothée ObachYazdan Yazdanpanah
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Ashish KumarUNKNOWN (The INASL Task-Force on Hepatocellular Carcinoma)
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Jeyamani Ramachandran
Dec 3, 2014·Surgical Oncology Clinics of North America·Kelly J LafaroTimothy M Pawlik
May 2, 2013·Journal of Clinical Gastroenterology·Sahil Mittal, Hashem B El-Serag
Mar 15, 2014·World Journal of Gastroenterology : WJG·Albert J Czaja
Feb 23, 2012·Digestive Diseases and Sciences·Amit G Singal, Jorge A Marrero
Aug 22, 2015·International Journal of Molecular Sciences·Roberta D'AmbrosioMassimo Colombo
Jan 29, 2016·Journal of Viral Hepatitis·A StubbsM Mutchnick
Nov 26, 2013·The Medical Clinics of North America·Reena Salgia, Amit G Singal
Oct 11, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Stuart C GordonUNKNOWN CHeCS Investigators
Aug 26, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Muhammad AliAmit G Singal
Apr 3, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Salvatore PettaUNKNOWN WEF Study Group
Oct 23, 2012·Infectious Disease Clinics of North America·Jennifer A Flemming, Norah A Terrault
Aug 7, 2012·Gastroenterology·Sylvie Deuffic-BurbanPhilippe Mathurin
Jun 28, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vivian Ng, Sammy Saab
Oct 10, 2015·Archives of Virology·Abdellah AkilAma Gassama-Diagne
Mar 15, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lisa I BackusLarry A Mole
Jan 25, 2011·Gastroenterology·Jennifer Y Chen, Raymond T Chung
Nov 22, 2015·Cancer Epidemiology·Patricia VillainRolando Herrero
Jan 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dorothée ObachSylvie Deuffic-Burban
Jul 21, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Leonard B Seeff

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