A sympathetic view on free radicals in diabetes

Neuron
Sabrina Diano, Tamas L Horvath

Abstract

Neuropathies are severe complications of diabetes. In this issue of Neuron, Campanucci et al. report that hyperglycemia-induced elevation of reactive oxygen species impairs synaptic transmission of sympathetic neurons leading to diabetes-induced dysautonomias. These observations provide new insights into the etiology of diabetic complications and suggest potential novel therapeutic approaches for neuropathies.

References

Apr 7, 2005·Lancet·Roy Freeman
May 18, 2007·Annual Review of Neuroscience·Qian Gao, Tamas L Horvath
Dec 17, 2008·Trends in Endocrinology and Metabolism : TEM·Tamas L HorvathSabrina Diano

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Citations

Jun 7, 2011·Neuroreport·Rachel Feldman-Goriachnik, Menachem Hanani
Sep 16, 2011·Trends in Molecular Medicine·Sabrina Diano, Tamas L Horvath

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