A symphony of inner ear developmental control genes.

BMC Genetics
Sumantra ChatterjeeT Lufkin

Abstract

The inner ear is one of the most complex and detailed organs in the vertebrate body and provides us with the priceless ability to hear and perceive linear and angular acceleration (hence maintain balance). The development and morphogenesis of the inner ear from an ectodermal thickening into distinct auditory and vestibular components depends upon precise temporally and spatially coordinated gene expression patterns and well orchestrated signaling cascades within the otic vesicle and upon cellular movements and interactions with surrounding tissues. Gene loss of function analysis in mice has identified homeobox genes along with other transcription and secreted factors as crucial regulators of inner ear morphogenesis and development. While otic induction seems dependent upon fibroblast growth factors, morphogenesis of the otic vesicle into the distinct vestibular and auditory components appears to be clearly dependent upon the activities of a number of homeobox transcription factors. The Pax2 paired-homeobox gene is crucial for the specification of the ventral otic vesicle derived auditory structures and the Dlx5 and Dlx6 homeobox genes play a major role in specification of the dorsally derived vestibular structures. Some Micro R...Continue Reading

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Citations

Sep 4, 2012·International Journal of Molecular Sciences·Hong PengShi-Jian Ding
Jan 1, 2011·Genetics Research International·Sumantra Chatterjee, Thomas Lufkin
Jan 11, 2013·Genetics Research International·Joel Sng, Thomas Lufkin
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Aug 22, 2021·Biochemical and Biophysical Research Communications·Yajie LuXin Cao

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Methods Mentioned

BETA
immunoprecipitation

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