PMID: 8942956Nov 26, 1996Paper

A synaptic basis for memory storage in the cerebral cortex

Proceedings of the National Academy of Sciences of the United States of America
M F Bear

Abstract

A cardinal feature of neurons in the cerebral cortex is stimulus selectivity, and experience-dependent shifts in selectivity are a common correlate of memory formation. We have used a theoretical "learning rule," devised to account for experience-dependent shifts in neuronal selectivity, to guide experiments on the elementary mechanisms of synaptic plasticity in hippocampus and neocortex. These experiments reveal that many synapses in hippocampus and neocortex are bidirectionally modifiable, that the modifications persist long enough to contribute to long-term memory storage, and that key variables governing the sign of synaptic plasticity are the amount of NMDA receptor activation and the recent history of cortical activity.

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Citations

Feb 13, 2001·Journal of Neuroscience Research·S Peña De Ortiz, Y Arshavsky
Nov 19, 2003·Hippocampus·Raby Bouras, C Andrew Chapman
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