A syndrome of transient encephalopathy associated with adenovirus infection

Pediatrics
R StraussbergJ Amir

Abstract

Adenovirus is a common pathogen in the pediatric population. Respiratory, gastrointestinal, or renal systems are often involved in adenovirus infections. Several neurologic syndromes have been attributed to adenovirus, such as adenovirus aseptic meningitis, myelitis, subacute focal encephalitis, and Reye-like syndrome. The purpose of this study was to describe the clinical features and encephalography findings in 7 infants treated in our center for a syndrome of transient encephalopathy associated with adenovirus infection. Three females and 4 males ages 7 to 34 months seen in our department between July 1983 and February 1984 and September 1998 and May 1999 presented with fever of at least 7 days' duration and a gradual decline in the state of alertness. Score on the Glasgow Coma Scale ranged from 9 to 12. Findings on lumbar puncture were normal. In all 7 patients, the encephalogram showed moderate to severe background slowing compatible with encephalopathy. All patients were catarrheal and had mild hepatomegaly with slight elevation of liver enzymes. Some had bronchopneumonia, diarrhea, and conjunctivitis either isolated or in combination. Adenovirus was isolated by immunfluorescence technique in all patients-from the sputum ...Continue Reading

Citations

Apr 27, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yhu-Chering HuangTzou-Yien Lin
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mong How OoiTom Solomon
Nov 16, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Henry F KrousHannah C Kinney
Nov 6, 2013·Emerging Infectious Diseases·Daisuke MoriKamruddin Ahmed
Mar 19, 2014·The Pediatric Infectious Disease Journal·Joaquin Reyes-AndradeOlaf Neth
Mar 20, 2010·Journal of Inherited Metabolic Disease·Irene M L W KeulartsNanda M Verhoeven-Duif
Mar 6, 2008·Neuroimaging Clinics of North America·Zoran Rumboldt
Nov 10, 2004·Brain & Development·Sachiko Onoe, Toshinori Nishigaki
May 16, 2006·Antiviral Research·L Lenaerts, L Naesens
Sep 17, 2004·Scandinavian Journal of Infectious Diseases·Koki NikaidoHiroyuki Tsutsumi
Dec 28, 2007·Journal of Child Neurology·Roni GefenEran Kozer
Oct 6, 2010·Neuro-ophthalmology·Mano S SiraGordon T Plant

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