PMID: 37843Aug 1, 1979

A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma?

Arthritis and Rheumatism
D E FurstN Roberts


Six long term survivors of bone marrow transplants developed a syndrome similar to progressive systemic sclerosis (PSS). Cutaneous involvement (6/6), pulmonary disease (6/6), musculoskeletal involvement (4/6), keratoconjunctivitis/positive Schirmer's test (4/6), Raynaud's phenomenon (2/6), and renal and cardiac disease (1/6) were similar to findings in PSS patients. T and B lymphocyte counts and functions were also similar. This PSS-like syndrome, including visceral involvement, after bone marrow transplantation lends support to an immunologic hypothesis of the pathogenesis of progressive systemic sclerosis.


Nov 1, 1992·Pediatric Pulmonology·E B KaplanC S August
Oct 6, 2007·Immunologic Research·Chris D Platsoucas, Emilia L Oleszak
Jun 29, 2004·La Revue de médecine interne·S VinzioB Goichot
Apr 14, 1999·Molecular Medicine Today·C M ArtlettS A Jimenez
Jul 20, 2002·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lars E French, Alain H Rook
Jul 31, 2013·Bone Marrow Transplantation·H M A HofsteeE H Serné
Nov 14, 2002·Annals of the Rheumatic Diseases·R GiacomelliS Bombardieri
Nov 26, 2010·Immunotherapy·Rebecca Manno, Francesco Boin
Mar 14, 2002·Current Rheumatology Reports·Yan Zhang, Anita C Gilliam
Dec 21, 2000·Current Rheumatology Reports·F ViganegoD E Furst
Dec 21, 2000·Current Rheumatology Reports·J L Nelson
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·F J Martinez-TelloS Madero-García
Jan 1, 1995·International Reviews of Immunology·A E Postlethwaite
Mar 1, 1990·The American Journal of the Medical Sciences·T Geppert
Aug 1, 2005·Reumatología clinica·A García-LópezR Parody
Jan 1, 1986·International Journal of Cell Cloning·K M Sullivan
Apr 1, 1990·Baillière's Clinical Rheumatology·C M Black
Feb 13, 2003·The Australasian Journal of Dermatology·Keng ChenStephen Shumack
Aug 1, 1991·Baillière's Clinical Rheumatology·J A Rennie, I A Auchterlonie
Jun 10, 2004·Arthritis and Rheumatism·Lazaros I Sakkas, Chris D Platsoucas
Aug 22, 2003·Bone Marrow Transplantation·R A Nash
Dec 1, 1979·The Medical Journal of Australia·G Spitzer
Oct 1, 1982·Arthritis and Rheumatism·J R SeiboldG P Rodnan
Jan 1, 1983·Arthritis and Rheumatism·A E Postlethwaite, A H Kang
Dec 1, 1980·Australian and New Zealand Journal of Medicine·J C Biggs
Sep 1, 1981·Arthritis and Rheumatism·P C DauR W Sagebiel
Mar 27, 2020·American Journal of Medical Genetics. Part a·Brandon N JohnsonDorret I Boomsma
Jun 18, 1998·Arquivos de neuro-psiquiatria·S M de AlmeidaE Ferreira


Dec 1, 1977·Annals of Internal Medicine·A A GratwohlA B Deisseroth
Dec 1, 1977·Annals of Internal Medicine·T J LawleyA B Deisseroth
Jan 1, 1978·Arthritis and Rheumatism·P J ClementsH E Paulus
May 1, 1977·Arthritis and Rheumatism·R FleischmajerJ R Reeves
Sep 24, 1977·British Medical Journal·T H Burns
Jul 1, 1976·The Journal of Clinical Investigation·R L Johnson, M ZIFF
Feb 1, 1976·Rheumatology and Rehabilitation·P Davis, M I Jayson
Mar 1, 1971·Transplantation·D P Sengar, P I Terasaki

Related Concepts

Hepatitis A
Graft Vs Host Reaction
Peeling Skin Syndrome
Immune complex
Transplantation, Homologous
Bone Marrow Cell Transplantation
Heart Diseases

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.