A synergistic role of convalescent plasma and mesenchymal stem cells in the treatment of severely ill COVID-19 patients: a clinical case report

Stem Cell Research & Therapy
Hongbing PengHonghui Li

Abstract

Acute respiratory distress syndrome virus-2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) infection, which causes global public health emergencies, has sped widely for more than 5 months and has the risk of long-term transmission. No effective treatment has been discovered to date. In the cases we report, the patient continued to deteriorate even after administration of antiviral drugs such as lopinavir/ritonavir, interferon-α, and ribavirin, as well as intravenous injection of meropenem, methylprednisolone, and immunoglobulin. So, we infused the patient with convalescent plasma (CP), and the absolute lymphocyte count increased the next day and returned to normal on the fourth day. Followed by intravenous infusion of mesenchymal stem cells (MSCs), bilateral infiltrates were absorbed and the pulmonary function was significantly improved. We note that the intravenous infusion of CP and MSCs for the treatment of severe COVID-19 patients may have synergistic characteristics in inhibiting cytokine storm, promoting the repair of lung injury, and recovering pulmonary function. We hope to provide a reference for the research direction of COVID-19 clinical strategies.

References

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Citations

Oct 13, 2020·The Cochrane Database of Systematic Reviews·Khai Li ChaiNicole Skoetz
Dec 19, 2020·International Immunopharmacology·Ying WangKun Zhu
Feb 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saniya MahendirattaBikash Medhi
May 21, 2021·The Cochrane Database of Systematic Reviews·Vanessa PiechottaNicole Skoetz
Jul 13, 2021·World Journal of Stem Cells·Amit SharmaBithiah Grace Jaganathan
Jul 29, 2021·Stem Cell Research & Therapy·Kátia Nunes da SilvaBruno Solano de Freitas Souza
Aug 28, 2021·World Journal of Transplantation·Hüseyin Sütlüoğlu, Öner Özdemir
Aug 31, 2021·BioMed Research International·María Verónica Cuevas-GonzalezJuan Carlos Cuevas-Gonzalez
Sep 10, 2021·Signal Transduction and Targeted Therapy·Lei ShiFu-Sheng Wang

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Methods Mentioned

BETA
ELISA
X-ray

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