Abstract
Acute respiratory distress syndrome virus-2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) infection, which causes global public health emergencies, has sped widely for more than 5 months and has the risk of long-term transmission. No effective treatment has been discovered to date. In the cases we report, the patient continued to deteriorate even after administration of antiviral drugs such as lopinavir/ritonavir, interferon-α, and ribavirin, as well as intravenous injection of meropenem, methylprednisolone, and immunoglobulin. So, we infused the patient with convalescent plasma (CP), and the absolute lymphocyte count increased the next day and returned to normal on the fourth day. Followed by intravenous infusion of mesenchymal stem cells (MSCs), bilateral infiltrates were absorbed and the pulmonary function was significantly improved. We note that the intravenous infusion of CP and MSCs for the treatment of severe COVID-19 patients may have synergistic characteristics in inhibiting cytokine storm, promoting the repair of lung injury, and recovering pulmonary function. We hope to provide a reference for the research direction of COVID-19 clinical strategies.
References
Dec 24, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ChengG Cheng
Sep 27, 2005·The Journal of Antimicrobial Chemotherapy·Kuo-Ming YehFeng-Yee Chang
Jun 4, 2014·Thorax·Sven AsmussenPerenlei Enkhbaatar
Jul 18, 2014·The Journal of Infectious Diseases·John Mair-JenkinsUNKNOWN Convalescent Plasma Study Group
Jan 31, 2018·Stem Cell Research & Therapy·Mahesh KhatriTea Meulia
Sep 6, 2019·Bioscience Reports·Dexiao KongChengyun Zheng
Jan 28, 2020·Lancet·Chaolin HuangBin Cao
Feb 3, 2020·Lancet·Nanshan ChenLi Zhang
Feb 6, 2020·Nature·Peng ZhouZheng-Li Shi
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 23, 2020·International Journal of Epidemiology·Noah C PeeriUbydul Haque
Mar 4, 2020·Intensive Care Medicine·Wei Zhang
Mar 15, 2020·Lancet·Fei ZhouBin Cao
Mar 29, 2020·JAMA : the Journal of the American Medical Association·Chenguang ShenLei Liu
Apr 3, 2020·Vox Sanguinis·Hoi-Kei Wong, Cheuk-Kwong Lee
Apr 4, 2020·Chest·Bin ZhangShuixing Zhang
Apr 8, 2020·Aging and Disease·Zikuan LengRobert Chunhua Zhao
Apr 25, 2020·Expert Opinion on Biological Therapy·Pietro Gentile, Aris Sterodimas
Apr 30, 2020·The Journal of Infectious Diseases·Qing-Lei ZengZhang-Suo Liu
May 6, 2020·Stem Cell Research & Therapy·Shan LiuLin Zou
May 8, 2020·Autoimmunity Reviews·Manuel RojasJuan-Manuel Anaya
May 19, 2020·Biotechnology Reports·Keshav RajarshiShashikant Ray
May 29, 2020·Stem Cell Research & Therapy·Yingxin ZhangChanghui Zhou
Jun 4, 2020·Aging and Disease·Pietro Gentile, Aris Sterodimas
Citations
Oct 13, 2020·The Cochrane Database of Systematic Reviews·Khai Li ChaiNicole Skoetz
Dec 19, 2020·International Immunopharmacology·Ying WangKun Zhu
Dec 29, 2020·Frontiers in Cardiovascular Medicine·Georgina M Ellison-HughesMark D Ross
Feb 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saniya MahendirattaBikash Medhi
Feb 27, 2021·Clinical and Translational Medicine·Xiaowei XuLanjuan Li
Mar 13, 2021·Biochimie·Songyue LouYongfang Yao
May 12, 2021·Journal of Translational Medicine·Wendi WangZhen-Ao Zhao
May 21, 2021·The Cochrane Database of Systematic Reviews·Vanessa PiechottaNicole Skoetz
May 25, 2021·Engineering·Li LiuLiming Cheng
Jun 3, 2021·Viruses·Saly Kanj, Basem Al-Omari
Jul 13, 2021·World Journal of Stem Cells·Amit SharmaBithiah Grace Jaganathan
Jul 29, 2021·Stem Cell Research & Therapy·Kátia Nunes da SilvaBruno Solano de Freitas Souza
Aug 28, 2021·World Journal of Transplantation·Hüseyin Sütlüoğlu, Öner Özdemir
Aug 31, 2021·BioMed Research International·María Verónica Cuevas-GonzalezJuan Carlos Cuevas-Gonzalez
Sep 10, 2021·Signal Transduction and Targeted Therapy·Lei ShiFu-Sheng Wang
Aug 22, 2021·Stem Cells and Development·Junwu WangLiang Zhang