A synthetic analogue of meiosis-activating sterol (FF-MAS) is a potent agonist promoting meiotic maturation and preimplantation development of mouse oocytes maturing in vitro

Human Reproduction
Carrie L Marín BivensJ J Eppig

Abstract

Follicular fluid-meiosis-activating sterol (FF-MAS) is a factor present in the pre-ovulatory follicle during the time of oocyte maturation. In mouse oocytes maturing in vitro, FF-MAS promotes the completion of meiotic maturation to metaphase II (MII) and improves competence to complete the 2-cell stage to blastocyst transition. We produced analogues of FF-MAS and selected three on the basis of potency to promote the resumption of meiosis by mouse oocytes maintained in meiotic arrest by hypoxanthine. The objective of this study was to determine whether these FF-MAS analogues also affect the quality of oocytes maturing in vitro with respect to the completion of meiotic maturation and augmenting the frequency of development to the blastocyst stage after fertilization in vitro. Cumulus cell-enclosed oocytes were isolated from the small antral follicles of 18 or 20 day post-natal mice. These oocytes normally have a reduced competence to complete meiotic maturation and preimplantation embryo development. Oocytes were isolated at the germinal vesicle stage and matured in vitro using media supplemented with 0.1% ethanol, 1 micromol/l FF-MAS, or 0.1-10 micromol/l FF-MAS analogues ZK255884 (884), ZK255933 (933) and ZK255991 (991). Oocyte...Continue Reading

References

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Citations

Aug 16, 2011·Zygote : the Biology of Gametes and Early Embryos·F Marco-JiménezM P Viudes-de-Castro
Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Lisa M Mehlmann
May 29, 2009·Animal Reproduction Science·Francisco Marco-JiménezJosé-Salvador Vicente
Jan 4, 2012·Molecular Reproduction and Development·Nucharin SongsasenDavid E Wildt
Aug 10, 2006·Molecular and Cellular Endocrinology·Knut R SteffensenClaus Yding Andersen
Mar 7, 2006·Molecular and Cellular Endocrinology·E Vrtacnik BokalD Rozman
Apr 20, 2016·Molecular Aspects of Medicine·Salwan MaqdasyJean-Marc A Lobaccaro
Dec 27, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert E ChapinJan-Bernd Stukenborg
Jul 26, 2018·International Journal of Molecular Sciences·Sarah DallelSalwan Maqdasy
Jul 11, 2006·Zygote : the Biology of Gametes and Early Embryos·Inger FaergeChristian Grøndahl
Jan 24, 2007·Human Reproduction Update·Darryl L Russell, Rebecca L Robker
Apr 3, 2010·Pharmacological Reports : PR·Jerzy Bełtowski, Andrzej Semczuk
Nov 2, 2019·International Journal of Molecular Sciences·Sheba JarvisCharlotte L Bevan

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