A synthetic erectile optogenetic stimulator enabling blue-light-inducible penile erection

Angewandte Chemie
Taeuk KimMartin Fussenegger

Abstract

Precise spatiotemporal control of physiological processes by optogenetic devices inspired by synthetic biology may provide novel treatment opportunities for gene- and cell-based therapies. An erectile optogenetic stimulator (EROS), a synthetic designer guanylate cyclase producing a blue-light-inducible surge of the second messenger cyclic guanosine monophosphate (cGMP) in mammalian cells, enabled blue-light-dependent penile erection associated with occasional ejaculation after illumination of EROS-transfected corpus cavernosum in male rats. Photostimulated short-circuiting of complex psychological, neural, vascular, and endocrine factors to stimulate penile erection in the absence of sexual arousal may foster novel advances in the treatment of erectile dysfunction.

References

Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·H C ChampionP J Kadowitz
Oct 18, 2000·International Journal of Impotence Research·J B McKinlay
Mar 10, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·J J DrabickR W Malone
Jul 12, 2002·The Journal of Gene Medicine·H MaruyamaF Gejyo
Sep 12, 2002·Biology of Reproduction·Thomas R MageeNestor F Gonzalez-Cadavid
Apr 18, 2003·BJU International·M B ChancellorN Yoshimura
Sep 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·George J ChristArnold Melman
Apr 12, 2005·The Journal of Urology·Nelson E BennettMichael B Chancellor
May 4, 2005·Pharmacology & Therapeutics·Noboru TodaTomio Okamura
Jan 3, 2006·The American Journal of Cardiology·Arthur L Burnett
Nov 4, 2006·World Journal of Urology·Jacques Buvat, Gilbert Bou Jaoudé
Jun 26, 2010·Frontiers in Behavioral Neuroscience·Dennis BellmannKlemens F Störtkuhl
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joshua P JohansenJoseph E LeDoux
Oct 1, 2010·Nature Methods·Tobias BruegmannPhilipp Sasse
Oct 30, 2010·The Journal of Biological Chemistry·Min-Hyung RyuMark Gomelsky
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Herbert E CovingtonEric J Nestler
Jun 3, 2011·Circulation·Bryan G Schwartz, Robert A Kloner
Jan 14, 2012·Current Opinion in Nephrology and Hypertension·Kenia Pedrosa NunesR Clinton Webb
Feb 5, 2013·Current Opinion in Neurobiology·Jonathan P Britt, Antonello Bonci
Jul 28, 2013·Science·Steve RamirezSusumu Tonegawa
Mar 13, 2014·The Journal of Sexual Medicine·Rodrigo A Fraga-SilvaNikolaos Stergiopulos
Jun 13, 2014·Current Diabetes Reviews·Ram Niwas Jangir, Gyan Chand Jain
Nov 12, 2014·Nature Communications·Marc FolcherMartin Fussenegger

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Citations

Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Pratik SaxenaMartin Fussenegger
Sep 4, 2015·Journal of Molecular Biology·Viktor Haellman, Martin Fussenegger
Aug 27, 2015·Nature Neuroscience·Karl Deisseroth
May 3, 2016·Current Opinion in Biotechnology·Mingqi XieMartin Fussenegger
Oct 31, 2016·Advanced Drug Delivery Reviews·Lies A L Fliervoet, Enrico Mastrobattista
May 6, 2016·Science Translational Medicine·Kate L MontgomeryScott L Delp
May 30, 2016·Current Opinion in Chemical Biology·Daniel Bojar, Martin Fussenegger
Oct 19, 2016·Nature Chemical Biology·Mette L SkjoedtJay D Keasling
Aug 29, 2016·Advanced Drug Delivery Reviews·I Cody MacDonald, Tara L Deans
Mar 25, 2017·Journal of Molecular Biology·Robert LindnerIlme Schlichting
Dec 13, 2016·Angewandte Chemie·Simon AusländerMartin Fussenegger
Mar 14, 2017·Current Opinion in Biotechnology·Vera JansenDagmar Wachten
Oct 6, 2017·Journal of Neural Engineering·Frédéric MichoudStéphanie P Lacour
Aug 5, 2017·The Journal of Physiological Sciences : JPS·Kamalesh K GuliaYoshimasa Koyama
Feb 6, 2017·Journal of Neural Engineering·Benjamin E MaimonHugh M Herr
Mar 20, 2018·Journal of Industrial Microbiology & Biotechnology·Mitchell S Weisenberger, Tara L Deans
Jan 16, 2019·Advanced Science·Maysam MansouriMartin Fussenegger
Feb 15, 2019·Biological Chemistry·Birthe StüvenAndreas Möglich
Sep 1, 2017·Porto Biomedical Journal·Fanny Michel, Marc Folcher
May 10, 2017·Nature Biomedical Engineering·Haifeng YeMartin Fussenegger
Apr 20, 2018·Chembiochem : a European Journal of Chemical Biology·Colin P O'Banion, David S Lawrence
Apr 24, 2019·Nature Biomedical Engineering·Ferdinand SedlmayerMartin Fussenegger
May 20, 2016·Cold Spring Harbor Perspectives in Biology·Simon Ausländer, Martin Fussenegger
Jul 27, 2018·International Journal of Impotence Research·Kyung-Jin OhKwangsung Park
Jul 14, 2019·Journal of Molecular Biology·Robert StabelAndreas Möglich
Nov 11, 2019·Emerging Topics in Life Sciences·Adam M VogelTara L Deans
Mar 14, 2019·Biological Chemistry·Birthe StüvenAndreas Möglich
Jun 9, 2021·Nature Communications·Maysam MansouriMartin Fussenegger
Jul 10, 2018·Chemical Reviews·Aba LosiAndreas Möglich

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