A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin

G GoldsteinJ Van Wauwe


The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32--36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This combination of actions is presently unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice; this also is a property of thymopoietin. These results suggest that this readily synthesized pentapeptide corresponds to an active site of thymopoietin and might serve as a therapeutic substitute for thymopoietin.


Sep 1, 1995·Journal of Peptide Science : an Official Publication of the European Peptide Society·I Z SiemionZ Wieczorek
Jun 1, 1989·Cellular and Molecular Neurobiology·E L OchoaM G McNamee
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J E BaierD Ricken
Jun 25, 1998·Immunologic Research·V K SinghS S Agarwal
Jan 1, 1986·Immunologic Research·G ChipensG Rosenthal
Nov 30, 1981·Biochimica Et Biophysica Acta·J B VaughnG Goldstein
Oct 23, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·P J LisiM Schiffman
Sep 24, 1987·Journal of Immunological Methods·E MétreauP Pradelles
Oct 1, 1992·Journal of the Neurological Sciences·B EymardS Berrih-Aknin
Jul 1, 1983·Mechanisms of Ageing and Development·V K GhantaR N Hiramoto
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·M P IuratoR Bernardini
Jan 1, 1991·Molecular Immunology·Z WieczorekI Z Siemion
Jul 1, 1994·Journal of Inorganic Biochemistry·I SóvágóO Nyéki
Jun 1, 1983·Immunopharmacology·M M Zatz, A L Goldstein
Jan 1, 1981·Pharmacology & Therapeutics·V Bocci
Jan 1, 1987·Pharmacology & Therapeutics·V Bocci
Jan 1, 1987·Veterinary Immunology and Immunopathology·T J Yang, E D Rabinovsky
Feb 1, 1982·Immunology Letters·M DardenneJ F Bach
Jul 20, 1988·Biochimica Et Biophysica Acta·A A AmoscatoG F Babcock
Jan 1, 1986·International Journal of Immunopharmacology·E RajnavölgyiJ Gergely
Jan 1, 1988·International Journal of Immunopharmacology·V Ruszala-MallonB S Wang
Jan 1, 1990·International Journal of Immunopharmacology·G A BelokrylovE I Sorochinskaya
Oct 1, 1992·International Journal of Immunopharmacology·G A BelokrylovV V Anokhina
Aug 1, 1992·International Journal of Immunopharmacology·E CillariM Dieli
Nov 1, 1993·International Journal of Immunopharmacology·G RavagnanE Garaci

Related Concepts

Structure-Activity Relationship
Lymphoid Cells
Receptors, Drug
Cell Differentiation Process
Hemolytic Complement
Mice, Nude
Thymus Hormones

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.