A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche

Stem Cells
Kouichi TabuTetsuya Taga

Abstract

Cancer stem cells (CSCs) are believed to be maintained within a microenvironmental niche. Here we used polymer microarrays for the rapid and efficient identification of glioma CSC (GSC) niche mimicries and identified a urethane-based synthetic polymer, upon which two groups of niche components, namely extracellular matrices (ECMs) and iron are revealed. In cultures, side population (SP) cells, defined as GSCs in the rat C6 glioma cell line, are more efficiently sustained in the presence of their differentiated progenies expressing higher levels of ECMs and transferrin, while in xenografts, ECMs are supplied by the vascular endothelial cells (VECs), including SP cell-derived ones with distinctively greater ability to retain xenobiotics than host VECs. Iron is stored in tumor infiltrating host macrophages (Mφs), whose protumoral activity is potently enhanced by SP cell-secreted soluble factor(s). Finally, coexpression of ECM-, iron-, and Mφ-related genes is found to be predictive of glioma patients' outcome. Our polymer-based approach reveals the intrinsic capacities of GSCs, to adapt the environment to organize a self-advantageous microenvironment niche, for their maintenance and expansion, which redefines the current concept of...Continue Reading

References

Mar 30, 2000·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·J SchlegelH Mennel
Mar 17, 2001·Nature Reviews. Genetics·N C Andrews
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Toru KondoTetsuya Taga
Oct 26, 2005·Neurosurgical Focus·Zita A SibenallerTimothy C Ryken
Jul 25, 2006·Nature Reviews. Cancer·Andrew I Minchinton, Ian F Tannock
Jan 16, 2007·Cancer Cell·Christopher CalabreseRichard J Gilbertson
Apr 19, 2007·Cancer Research·Xuesheng ZhengWeiguo Liu
Nov 8, 2007·Nature Reviews. Molecular Cell Biology·Ivana De DomenicoJerry Kaplan
Jun 6, 2009·Cell Stem Cell·Kevin Woolard, Howard A Fine
May 11, 2010·Cell Stem Cell·Justin D LathiaJeremy N Rich
Jun 1, 2010·Nature Biotechnology·Luis G Villa-DiazGary D Smith
Nov 26, 2010·Nature·Rong WangViviane Tabar
Mar 9, 2011·International Journal of Hematology·Kazuhito Naka, Atsushi Hirao
Jun 19, 2012·Cell Stem Cell·Jane E Visvader, Geoffrey J Lindeman
Apr 8, 2015·Nature Genetics·Hiromichi SuzukiSeishi Ogawa

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Citations

Jan 26, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasuhiro KokubuTetsuya Taga
Jun 18, 2017·Regenerative Medicine·Khushboo GulatiKrishna Mohan Poluri
Feb 22, 2018·International Journal of Radiation Biology·Junfeng LiuFei Ye
May 23, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sara SchmidtMark Bradley
Jan 17, 2020·Advanced Healthcare Materials·Yichuan ZhangChris I De Zeeuw
Mar 31, 2021·Nature Biomedical Engineering·Jun SuzukaShinya Tanaka

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