DOI: 10.1101/482760Nov 30, 2018Paper

A System Biology Approach to Identify the Genetic Markers to the progression of Parkinson's disease for Aging, lifestyle and Type 2 Diabetes

BioRxiv : the Preprint Server for Biology
Najmus SakibMohammad Ali Moni

Abstract

Actual causes of Parkinson's disease (PD) are still unknown. In any case, a better comprehension of genetic and ecological influences to the PD and their interaction will assist physicians and patients to evaluate individual hazard for the PD, and definitely, there will be a possibility to find a way to reduce the progression of the PD. We introduced quantitative frameworks to reveal the complex relationship of various biasing genetic factors for the PD. In this study, we analyzed gene expression microarray data from the PD, ageing (AG), severe alcohol consumption (AC), type II diabetes (T2D), high body fat (HBF), hypercholesterolemia (HC), high dietary fat (HDF), red meat dietary (RMD), sedentary lifestyle (SL), smoking (SM), and control datasets. We have developed genetic associations of various factors with the PD based on the neighbourhood-based benchmarking and multilayer network topology. We identified 1343 significantly dysregulated genes in the PD patients compared to the healthy control, where we have 779 genes down-regulated and 544 genes up-regulated. 69 genes were highly expressed in both for the PD and alcohol consumption whereas the number of shared genes for the PD and the type II diabetes is 51. However, the PD ...Continue Reading

Related Concepts

Aging
Anatomy, Regional
Diabetes Mellitus, Non-Insulin-Dependent
Dietary Fats
Down-Regulation
Gene Expression
Genes
Hypercholesterolemia
Parkinson Disease
Physicians

Related Feeds

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Cell Aging (Preprints)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.