PMID: 7085004Jan 1, 1982Paper

A system of alloantigens that selectively identifies lymph-node lymphocytes

Immunogenetics
F W ShenE A Boyse

Abstract

The antiserum (BALB.I-H-2j x SWR/J)F1 anti-I.29 ascites cells, in reaction with B6 lymph-node cells (LNC) in the cytotoxicity assay, defines an alloantigen system called Lna-1 (lymph-node alloantigen-l) which in normal, untreated mice is expressed on the cells of lymph nodes but not of other lymphoid organs. The T- and B-cell populations of lymph nodes evidently include Lna-1+ subpopulations representing 30-40 percent of the total population The Lna-+ phenotype could be induced on cells of thymus and spleen but not of bone marrow. Congenitally asplenic +/Dh mice have no Lna-1+ cells in their lymph nodes, but their LNC can be induced to express Lna-1; this suggests that the spleen is normally required for the differentiation of Lna-1+ cells from Lna-1- precursors. It is not yet known whether thymus is also required for the expression of Lna-1 in lymph nodes. It remains to be seen whether the existence of the Lna-1+ B-cell subpopulation of lymph nodes depends on Lna-1+ T cells, and whether the Lna-1+ phenotype of B cells may be acquired rather than intrinsic. One hypothesis which is the basis of further study is that there is a T-cell pathway in which noninducible bone-marrow cells become Lna-1-inducible in the thymus, then trave...Continue Reading

References

Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C S DavidJ A Frelinger

Citations

Dec 1, 1989·Journal of Surgical Oncology·S S AmrM S Tarawneh
Jan 1, 1986·Immunogenetics·G K MatsushimaJ A Frelinger
Mar 1, 1986·Immunology Letters·L Kreja, H J Seidel
Apr 1, 1991·Immunological Reviews·L Van KaerS Tonegawa
Oct 1, 1995·Immunological Reviews·H CheroutreW D Huse
May 13, 1999·Immunological Reviews·C AmadouK F Lindahl
Aug 1, 1989·Journal of Immunogenetics·M Oudshoorn-Snoek, P Démant
Jan 1, 1982·Immunological Reviews·F W ShenJ S Tung
Jul 15, 1984·International Journal of Cancer. Journal International Du Cancer·A Peled, N Haran-Ghera

Related Concepts

Bone Marrow Cells
Microcytotoxicity Test
Alloantigens
Lymph Nodes
Lymphoid Cells
Mice, Inbred Strains
Spleen
Thymus Gland

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