A systematic assessment of the use of platelet-rich plasma in spinal fusion

Annals of Biomedical Engineering
Benjamin D ElderTimothy F Witham

Abstract

Spinal fusion is one of the most commonly performed procedures for the treatment of spinal instability caused by a multitude of pathologies. However, despite significant advances in spinal instrumentation, failed fusion, or pseudoarthrosis, remains a significant challenge. Therefore, other additives such as bone graft extenders and growth factors have been explored as a method to augment fusion rates. Platelet-rich plasma (PRP) represents an additional approach, as it has shown some promise in bone regeneration. While the general use of PRP in orthopedic applications has been reviewed previously, its use in spinal fusion has not been systematically analyzed. The objective of this review is to systematically discuss the role of PRP in augmentation of bone regeneration for the purpose of spinal fusion. Background information on PRP, including a discussion of its preparation, activation, and growth factors, is included. Additionally, data from in vitro studies utilizing PRP in bone tissue engineering strategies is analyzed, and the available animal and clinical studies are systematically reviewed in order to provide guidance on future research pathways as well as the potential role of PRP in spinal fusion surgery.

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Citations

Dec 8, 2016·World Neurosurgery·Benjamin D Elder, Timothy F Witham
May 19, 2017·Tissue Engineering. Part B, Reviews·Rui M DuarteJorge Correia-Pinto
Feb 25, 2020·Journal of Craniovertebral Junction and Spine·Joseph Gamal BoktorYasser Elmiligui
May 27, 2020·Advances in Orthopedics·Daudi R ManiniYuXiang Wang
Dec 5, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tucker C CallananFrank P Cammisa
Jun 14, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Giuseppe Roberto GiammalvaRosario Maugeri
Sep 7, 2021·Frontiers in Bioengineering and Biotechnology·Jeffrey L Van EpsBradley K Weiner

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