A systematic comparison of the actual, potential, and theoretical health effects of cobalt and chromium exposures from industry and surgical implants

Critical Reviews in Toxicology
Gemma M KeeganC P Case

Abstract

Humans are exposed to cobalt (Co) and chromium (Cr) from industry and surgical devices, most notably orthopedic joint replacements. This review compares the potential health effects of exposure to Co and Cr contaminants from these two different sources, both in the locally exposed tissues and at sites distant to the primary exposure. Surgical implantation results largely in exposures to ions, corrosion products, and particles of Co and Cr. Industrial exposures are predominantly to metal compounds and particles. Although there are large literatures on industrial and surgical exposures to these metals, there has yet to be a systematic comparison of the two to test whether more general lessons might be learned about the human toxicology of Co and Cr. Both industrial and surgical exposures cause inflammatory and other immune reactions in the directly exposed tissues. In the lung there is a well-established risk of cancer following long-term exposures to hexavalent Cr; however, the development of sarcoma in the connective tissues adjacent to implants in response to metal particles is rare. Both types of exposure are associated with changes in the peripheral blood, including evidence of oxidative stress, and altered numbers of circul...Continue Reading

References

Jul 23, 1976·Archiv Für Orthopädische Und Unfall-Chirurgie·R G Volz
Apr 1, 1992·Scandinavian Journal of Work, Environment & Health·E PrescottJ M Christensen
May 1, 1991·The American Review of Respiratory Disease·S J Sferlazza, W S Beckett
Aug 1, 1990·Environmental Health Perspectives·D A Savitz, J H Chen
Aug 1, 1988·The Journal of Bone and Joint Surgery. British Volume·W J GillespieP M Ryan
Jul 1, 1995·Lancet·G D NuytsM E De Broe
May 1, 1995·Journal of Biomedical Materials Research·K Merritt, S A Brown
Apr 21, 1995·The Science of the Total Environment·J M Christensen
Feb 1, 1995·Regulatory Toxicology and Pharmacology : RTP·G Oberdörster
Nov 1, 1994·Journal of Biomedical Materials Research·J Yang, K Merritt
Jun 30, 1994·The Science of the Total Environment·R Lauwerys, D Lison
Jun 30, 1994·The Science of the Total Environment·P SeghizziG Mosconi
Jun 30, 1994·The Science of the Total Environment·P ApostoliL Alessio
Jun 30, 1994·The Science of the Total Environment·I FranchiniE Bergamaschi
Jun 30, 1994·The Science of the Total Environment·F D'AddaP Seghizzi
Jun 30, 1994·The Science of the Total Environment·M MiglioriP Seghizzi
Jun 30, 1994·The Science of the Total Environment·E SabbioniG Scansetti
Jun 30, 1994·The Science of the Total Environment·A M Cirla
May 1, 1994·The Journal of Bone and Joint Surgery. American Volume·S S UpadhyayA C Yau
Jan 1, 1993·International Archives of Occupational and Environmental Health·H J RaithelG Lehnert
Mar 1, 1996·Occupational and Environmental Medicine·Y KusakaS Goto
Aug 1, 1996·Clinical Orthopaedics and Related Research·T VisuriE B Riska
Jan 1, 1996·Human & Experimental Toxicology·J P Bonde, E Vittinghus
Feb 1, 1997·American Journal of Industrial Medicine·T F Mancuso
Feb 1, 1997·American Journal of Industrial Medicine·T F Mancuso
Feb 1, 1997·The Prostate·J W van der Gulden
Nov 1, 1995·Human Reproduction Update·W OmbeletO Steeno
Apr 1, 1997·Scandinavian Journal of Work, Environment & Health·J J Moulin
Jan 1, 1997·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P A RevellA Kobayashi
Jul 1, 1997·Clinical Orthopaedics and Related Research·Y KadoyaM A Freeman
Aug 1, 1997·Regulatory Toxicology and Pharmacology : RTP·D J PaustenbachD M Proctor
Aug 1, 1997·Regulatory Toxicology and Pharmacology : RTP·L W Miksche, J Lewalter
Mar 5, 1998·The Journal of Bone and Joint Surgery. American Volume·J J JacobsR M Urban
Apr 16, 1998·Journal of Toxicology and Environmental Health. Part a·Q ZhangK Donaldson
Jun 13, 1998·Occupational and Environmental Medicine·T SorahanJ M Harrington
Jul 11, 1998·Journal of Biomedical Materials Research·S M HorowitzC K Ritchie
Sep 28, 1998·International Archives of Occupational and Environmental Health·C S LiuT I Lin
Oct 17, 1998·Toxicology and Applied Pharmacology·M D CohenR B Schlesinger
Oct 17, 1998·Acta Anaesthesiologica Scandinavica·G NergeliusE Vinge
Nov 4, 1998·The Journal of Bone and Joint Surgery. American Volume·J J JacobsJ O Galante

❮ Previous
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Citations

Oct 29, 2011·Biology of Reproduction·Patrick J DevineUlrike Luderer
Mar 10, 2012·BMC Musculoskeletal Disorders·Michael PleckoBrigitte von Rechenberg
May 21, 2013·Toxicology and Applied Pharmacology·Francesca RovettaMaria Francesca Aleo
Mar 7, 2014·Dental Materials : Official Publication of the Academy of Dental Materials·Yolanda S HedbergInger Odnevall Wallinder
Jun 4, 2014·The Journal of Arthroplasty·Annamaria NicolliAndrea Trevisan
May 26, 2010·Pharmaceuticals·Eddie L ChangD Andrew Knight
Oct 4, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hyun-Jung ChoiSoo-Youn Lee
Feb 26, 2016·Toxicology and Applied Pharmacology·Sandra S WiseJohn Pierce Wise
Aug 21, 2012·Journal of Pediatric Surgery·Thomas P Cundy, Christopher P Kirby
Dec 17, 2011·European Journal of Pharmacology·Jocelyn M MadeiraAndis Klegeris
Mar 19, 2011·Toxicology·Klaudia Jomova, Marian Valko
Jul 31, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·María Rodríguez de la FlorJosé Manuel Fernández-Carreira
Oct 25, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yolanda Hedberg, Inger Odnevall Wallinder
May 10, 2013·Critical Reviews in Toxicology·Dennis J PaustenbachBrent D Kerger
Aug 13, 2011·International Journal of Occupational Medicine and Environmental Health·Carina CassiniMirian Salvador
Oct 19, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Alina BeraudiAldo Toni
Sep 6, 2014·The Angle Orthodontist·Ayse Tuygun ErdoganFikrettin Sahin
Apr 4, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Susanne Bendesgaard PedersenHenrik Toft Sørensen
May 30, 2013·Reproductive Toxicology·Karin S HougaardUlla Vogel
Mar 1, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Claudia N MartiniMaría del C Vila
Jul 9, 2013·Acta Biomaterialia·Morteza Haeri, Jeremy L Gilbert
Sep 18, 2012·Regulatory Toxicology and Pharmacology : RTP·Brent L FinleyShannon H Gaffney
Jun 27, 2012·The Science of the Total Environment·Lars Ole SimonsenPoul Bennekou
Jun 22, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Emmanuel GibonStuart B Goodman
Oct 6, 2012·Lancet·Alison J SmithUNKNOWN National Joint Registry for England and Wales
Sep 30, 2010·Journal of Biomaterials Applications·Masahiro YamadaTakahiro Ogawa

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