A systematic literature review of efficacy, effectiveness and safety of biologic therapies for treatment of familial Mediterranean fever.

Rheumatology
Jasmin B Kuemmerle-DeschnerPeter Hur

Abstract

To identify and summarize the existing evidence on the efficacy, effectiveness and safety of biologic therapies used, either as indicated or off-label, in the treatment of FMF. A systematic literature review was conducted using Embase®, MEDLINE®, MEDLINE®-In Process, and Cochrane databases to identify randomized/non-randomized controlled trials (RCTs/non-RCTs) and real-world observational studies of FMF published as full-text articles (2000-September 2017) or conference abstracts (2014-September 2017). Studies with data for ≥1 biologic were included. Studies with <5 patients were excluded. Of the 3342 retrieved records, 67 publications, yielding 38 unique studies, were included. All studies were published after the year 2010, and the majority (21) were full-text articles. Most studies (33/38) were prospective/retrospective observational; three were double-blind, placebo-controlled RCTs (one each of anakinra, canakinumab and rilonacept); and two were non-RCTs (both canakinumab). Anakinra (26), canakinumab (21) and etanercept (6) were the most frequently used biologics across studies, whereas use of adalimumab, tocilizumab, rilonacept and infliximab was limited (1-2 studies). The available evidence suggested benefits of anakinra ...Continue Reading

References

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Sep 1, 1997·Nature Genetics·UNKNOWN French FMF Consortium
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Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
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Jan 2, 2013·The American Journal of the Medical Sciences·Ozgur AkgulSalih Ozgocmen
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Jun 23, 2016·Modern Rheumatology·Orhan KucuksahinSukran Erten
Jan 4, 2017·The Journal of Rheumatology·Katerina LaskariPetros P Sfikakis
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Jan 29, 2019·La Presse médicale·Huri Ozdogan, Serdal Ugurlu

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Citations

Oct 21, 2020·QJM : Monthly Journal of the Association of Physicians·Bugra Han Egeli, Serdal Ugurlu
Jun 7, 2021·Advances in Rheumatology·Hülya KaçmazNuray Aktay Ayaz
May 8, 2021·Rheumatology·Jurgen SotaUNKNOWN Autoinflammatory Diseases Alliance (AIDA) and the Autoinflammatory Diseases Working Group of the Italian Society of Rheumato
Nov 21, 2021·British Journal of Clinical Pharmacology·Dimitri PoddigheErkan Demirkaya

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