A Systematic Review and Meta-Analysis Comparing Programmed Intermittent Bolus and Continuous Infusion as the Background Infusion for Parturient-Controlled Epidural Analgesia

Scientific Reports
Jiqian XuShanglong Yao

Abstract

The programmed intermittent epidural bolus (PIEB) technique offers multiple benefits over continuous epidural infusion (CEI), but controversy still exists when it is used in conjunction with a parturient-controlled epidural analgesia (PCEA) regimen. A systematic review and meta-analysis was thus conducted using the Medline, EMBASE, CENTRAL and Web of Science databases with the aim of identifying those randomized controlled trials (RCTs) that performed a comparison between PIEB and CEI in healthy parturients using a PCEA regimen with regard to the duration of labor, labor pain, anesthesia interventions, maternal satisfaction and main side effects. The data were analyzed using a random-effects model. Eleven eligible trials were included, in which 717 participants were allocated to the PIEB + PCEA group and 650 patients were allocated to the CEI + PCEA group. The rate of instrumental delivery, incidence of breakthrough pain, PCEA usage rates and local anesthetic usage were significantly reduced, the labor duration was statistically shorter, and the maternal satisfaction score was significantly improved in the PIEB + PCEA group compared with that in the CEI + PCEA group. There were no differences in the side effects between the two...Continue Reading

References

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Citations

Sep 6, 2019·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Jessica TurnerSailesh Kumar
Jul 24, 2020·Paediatric Anaesthesia·Rajiv BalyanVidya Chidambaran
Oct 1, 2020·International Journal of Environmental Research and Public Health·I-Shiang TzengKuo-Hu Chen
Dec 15, 2020·Current Opinion in Anaesthesiology·Emilia GuaschFernando Gilsanz
Oct 24, 2020·Paediatric Drugs·Christopher S LeeVidya Chidambaran
Nov 3, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Yusuke MazdaJose C A Carvalho
Jan 29, 2022·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Elliott CallahanRonald B George

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