A systematic review and meta-analysis of plasma amyloid 1-42 and tau as biomarkers for Alzheimer's disease

SAGE Open Medicine
Keerthanaa Balasubramanian ShanthiP Rani

Abstract

Amyloid 1-42 (Aβ42) and tau in cerebrospinal fluid are currently used as markers for diagnosis of Alzheimer's disease. Conflicting reports exist regarding their plasma levels in Alzheimer's disease patients. A meta-analysis was performed to statistically validate the use of plasma Aβ42 and tau as biomarkers for Alzheimer's disease. Different databases were searched using the search key: (amyloid OR amyloid1-42 OR Aβ42) AND (tau OR total tau) AND plasma AND (alzheimer's OR alzheimer's disease), and for databases not accepting boolean search, records were retrieved using the search key: plasma + amyloid + tau + alzheimer's. A total of 1880 articles for Aβ42 and 1508 articles for tau were shortlisted. The abstracts were screened, and 69 articles reporting plasma Aβ42 levels and 6 articles reporting plasma tau were identified. After exclusion, 25 studies reporting plasma Aβ42 and 6 studies reporting total tau were analysed in Review Manager version 5.2 using weighted mean difference method, and the bias between studies was assessed using the funnel plot. Plasma Aβ42 and tau did not vary significantly between Alzheimer's disease patients and controls. The funnel plot showed that there was no bias between studies for Aβ42, while poss...Continue Reading

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Mar 10, 2017·Journal of Epidemiology and Community Health·Maria K LuojusJussi Kauhanen
Feb 24, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Michael L AloscoRobert A Stern
Aug 5, 2017·Frontiers in Neurology·Palaniswamy RaniChellappa Rani Cathrine
Mar 25, 2019·Dementia and Neurocognitive Disorders·YoungSoon YangSangYun Kim
May 20, 2020·Translational Psychiatry·André F CarvalhoNathan Herrmann
Jan 31, 2021·BMC Veterinary Research·Sataporn PhochantachindaDuangthip Chatchaisak

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Methods Mentioned

BETA
ELISA
glycosylation
array technology

Software Mentioned

Review Manager ( RevMan )

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