A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Christopher CaoTristan D Yan

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive disease of the pleural lining with a dismal prognosis. Surgical treatments of MPM with a curative intent include extrapleural pneumonectomy and extended pleurectomy/decortication (P/D). This meta-analysis aimed to compare the perioperative and long-term outcomes of EPP and extended P/D for selected surgical candidates. A systematic review of the literature was performed on six electronic databases to identify all relevant data on comparative outcomes of extended P/D and EPP in a multimodality setting. Endpoints included perioperative mortality and morbidity, as well as long-term overall survival. Seven relevant studies with comparative data on EPP (n=632) versus extended P/D (n=513) were identified from the current literature. Comparison of these two groups demonstrated significantly lower perioperative mortality (2.9% vs. 6.8%, p=0.02) and morbidity (27.9% vs. 62.0%, p<0.0001) for patients who underwent extended P/D compared to EPP. Median overall survival ranged between 13-29 months for extended P/D and 12-22 months for EPP, with a trend favouring extended P/D. Although it must be emphasized that patient selection and treatment strategies differ between EPP and extended P/...Continue Reading

References

Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Raja M Flores
Feb 3, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Valerie W Rusch
Apr 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Federico ReaFrancesco Sartori
Apr 13, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W WederUNKNOWN Swiss Group for Clinical Cancer Research
Oct 3, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tom Treasure, Martin Utley
Dec 1, 2007·Interactive Cardiovascular and Thoracic Surgery·Morihito OkadaNoriaki Tsubota
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee M KrugNicholas J Vogelzang
Jun 24, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Arman HasaniAnna K Nowak
Aug 8, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tom TreasureJulian Peto
Sep 22, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tom Treasure
Oct 14, 2009·Seminars in Thoracic and Cardiovascular Surgery·Andrea S WolfDavid J Sugarbaker
Mar 4, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Valerie W Rusch
Jun 8, 2010·The European Respiratory Journal·P E Van SchilUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC) Lung Cancer Group
Aug 31, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Christopher Q CaoBrian C McCaughan
Aug 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·David RiceUNKNOWN International Association for the Study of Lung Cancer International Staging Committee and the International Mesothelioma In
Nov 2, 2011·The Lancet Oncology·Walter WederNico van Zandwijk
Jan 6, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Apostolos NakasDavid Waller
Jan 17, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ottavio Rena, Caterina Casadio
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Loïc Lang-LazdunskiJames Spicer
Feb 23, 2013·Asian Cardiovascular & Thoracic Annals·Till PloenesBernward Passlick
Jun 19, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Christopher CaoTristan D Yan

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Citations

Mar 19, 2014·General Thoracic and Cardiovascular Surgery·Seiki Hasegawa
Dec 3, 2014·Thoracic Surgery Clinics·Andrea S Wolf, Raja M Flores
Apr 29, 2015·The Annals of Thoracic Surgery·Camille MunckNacim Betrouni
Nov 28, 2015·The Journal of Thoracic and Cardiovascular Surgery·Hasan Fevzi BatirelMustafa Yuksel
Aug 12, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tomoko YamagishiTakumi Kishimoto
Dec 8, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Annabel J SharkeyDavid A Waller
Dec 2, 2015·Clinical & Experimental Metastasis·Tomoko YamagishiTakumi Kishimoto
Mar 24, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Pierre MordantMarc de Perrot
Nov 23, 2015·Surgery Today·Teruhisa Takuwa, Seiki Hasegawa
Nov 22, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Arthur KostronIsabelle Opitz
Jun 6, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·R A DamhuisJ P van Meerbeeck
Jun 16, 2015·Seminars in Thoracic and Cardiovascular Surgery·Christopher CaoTristan D Yan
Mar 26, 2016·Expert Review of Respiratory Medicine·Pietro Bertoglio, David A Waller
Apr 8, 2016·Expert Opinion on Pharmacotherapy·C MaggioniF Grossi
Feb 3, 2015·The Annals of Thoracic Surgery·Loic Lang-Lazdunski
Dec 24, 2014·The Annals of Thoracic Surgery·Emanuela TaioliRaja M Flores
May 14, 2016·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M SchirrenJ Schirren
Jun 12, 2016·Critical Reviews in Oncology/hematology·S NovelloG Scagliotti
Jun 23, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Maurizio InfanteMarco Alloisio
Jul 19, 2016·Thoracic Surgery Clinics·Andrea S Wolf, Raja M Flores
Dec 8, 2016·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Francesco Paolo CaroniaEttore Arrigo
Mar 28, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fauzia ShaikhAndreas Rimner
Jun 2, 2018·The Korean Journal of Thoracic and Cardiovascular Surgery·Seung Ri KangYong-Hee Kim
Jun 16, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I Opitz, W Weder
Oct 8, 2018·Journal of Surgical Oncology·Maaike van GerwenEmanuela Taioli
Oct 31, 2018·General Thoracic and Cardiovascular Surgery·Dimitrios E MagouliotisKalliopi Athanassiadi
Dec 3, 2016·European Respiratory Review : an Official Journal of the European Respiratory Society·Anna C BibbyIoannis Psallidas
Mar 17, 2017·The European Respiratory Journal·Arnaud Scherpereel
Apr 13, 2019·Expert Review of Respiratory Medicine·Kyrillus Shohdy, Omar Abdel-Rahman
Oct 10, 2019·Expert Review of Respiratory Medicine·Giovanni Luca Ceresoli, Antonio Rossi
Oct 10, 2019·Expert Review of Respiratory Medicine·Kozo KuribayashiTakashi Kijima
Jan 19, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hedy L KindlerRaffit Hassan
Apr 30, 2017·Interactive Cardiovascular and Thoracic Surgery·Arthur KostronIsabelle Opitz

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