A systematic review and meta-analysis of the long-term overall outcome of autism spectrum disorders in adolescence and adulthood

Acta Psychiatrica Scandinavica
H-C SteinhausenM B Lauritsen

Abstract

A systematic review and meta-analysis of studies reporting on the overall outcome in terms of a global measure of adjustment in children with autistic disorders followed up in adolescence and adulthood. PubMed, PsycINFO, and EMBASE were systematically searched on 3rd of August 2015. Included studies were analyzed using random-effects models estimating event rates (%) and 95% confidence intervals (95%CI). From 4350 records identified in the search, 15 studies covering 12 unique samples and a total of N = 828 individuals with autistic disorders were included in the analyses. An estimated 19.7% (95%CI: 14.2-26.6) had a good outcome, 31.1% (95%CI: 23.2-40.4%) a fair outcome, and 47.7% (95%CI: 36.6-59.0) a poor outcome. The meta-analysis showed strong evidence for heterogeneity. The subtype of childhood autism is a significant moderating factor on the risk of having a poor outcome at follow-up, whereas age at follow-up showed statistically significant but inconsistent associations with outcome status. The long-term outcome of almost half of all individuals with autistic disorders is poor. The subtype of autism in childhood may be a predictor for specific long-term outcomes, but in general, little is known about the pathways and pred...Continue Reading

References

Sep 1, 1992·Journal of Autism and Developmental Disorders·R KobayashiK Yoshinaga
Jun 1, 1989·Journal of Autism and Developmental Disorders·P SzatmariS Rich
Jul 1, 1985·Journal of the American Academy of Child Psychiatry·J M RumseyW R Sceery
Jan 1, 1974·Journal of Autism and Childhood Schizophrenia·V Lotter
Jul 1, 1973·Journal of Autism and Childhood Schizophrenia·M K DeMyerR Steele
Nov 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·M RutterL Lockyer
Aug 18, 2000·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P HowlinM Rutter
Mar 18, 2003·Autism : the International Journal of Research and Practice·I EngströmB Emilsson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Patricia HowlinMichael Rutter
Aug 27, 2005·Journal of Autism and Developmental Disorders·Eva BillstedtChristopher Gillberg
Mar 7, 2007·Journal of Autism and Developmental Disorders·Mats CederlundChristopher Gillberg
Sep 4, 2007·Journal of Autism and Developmental Disorders·Linda C Eaves, Helena H Ho
Jan 16, 2009·American Journal on Intellectual and Developmental Disabilities·Patricia HowlinTony Charman
May 14, 2009·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Sigmund EldevikScott Cross
May 21, 2009·Autism Research : Official Journal of the International Society for Autism Research·Megan A FarleyHilary Coon
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Jun 22, 2010·American Journal on Intellectual and Developmental Disabilities·Anna J EsbensenJulie Lounds Taylor
Dec 22, 2011·Journal of Autism and Developmental Disorders·Kristen Gillespie-LynchTed Hutman
Mar 1, 2012·Journal of Autism and Developmental Disorders·Somer L Bishop, Marsha Mailick Seltzer
May 2, 2012·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Patricia Howlin, Philippa Moss
Aug 24, 2012·Autism : the International Journal of Research and Practice·Natalie A Henninger, Julie Lounds Taylor
Sep 21, 2012·BMC Psychiatry·Lars ClemmensenHans-Christoph Steinhausen
Jan 17, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Deborah FeinKatherine Tyson
May 25, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Patricia HowlinMichael Rutter
Jul 16, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Patricia HowlinMichael Rutter
Feb 21, 2014·Journal of Autism and Developmental Disorders·Christina Mohr JensenMarlene Briciet Lauritsen
May 7, 2014·Journal of Developmental and Behavioral Pediatrics : JDBP·Alyssa J OrinsteinDeborah A Fein

❮ Previous
Next ❯

Citations

Oct 18, 2016·Gerontology & Geriatrics Education·Scott D WrightAmy Maida Wadsworth
Jan 10, 2017·Current Opinion in Psychiatry·Patricia Howlin, Iliana Magiati
Jul 2, 2017·Autism : the International Journal of Research and Practice·Lauren Bishop-FitzpatrickShaun M Eack
May 8, 2018·Autism Research : Official Journal of the International Society for Autism Research·David MasonJeremy R Parr
Jan 13, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Julie-Anne Little
May 20, 2017·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Inge Kamp-Becker, Luise Poustka
Apr 11, 2018·Autism : the International Journal of Research and Practice·Alasdair ChurchardWilliam Mandy
Dec 5, 2019·Journal of Abnormal Child Psychology·Elizabeth PellicanoLorcan Kenny
Dec 6, 2019·Current Pharmaceutical Design·Victor RuggieriClaudia Arberas
May 1, 2020·Psychological Medicine·Guan-Jye SengSusan Shur-Fen Gau
Nov 28, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dong-Mei WuYuan-Lin Zheng
Mar 22, 2018·European Child & Adolescent Psychiatry·I Kamp-BeckerS Stroth
Mar 9, 2019·Scientific Reports·Way K W LauBenson W M Lau
Oct 11, 2016·Neural Plasticity·Eyal AronoffMichael Leon
Apr 4, 2017·Indian Pediatrics·UNKNOWN National Consultation Meeting for Developing IAP Guidelines on Neuro Developmental Disorders under the aegis of IAP ChildhooM K C Nair
Nov 27, 2019·Autism in Adulthood : Challenges and Management·Anne V KirbyJarrett Henderson
Aug 8, 2020·Autism : the International Journal of Research and Practice·Nick WarrenValerie D'Astous
Dec 22, 2017·Autism Research : Official Journal of the International Society for Autism Research·Megan FarleyWilliam McMahon
Oct 3, 2018·Autism Research : Official Journal of the International Society for Autism Research·Amaria BaghdadliLaurent Mottron
Dec 4, 2019·Annals of General Psychiatry·Isaia SevaslidouGrigoris Abatzoglou
Jun 14, 2019·Frontiers in Psychiatry·Delphine JacobsKristien Hens
Jun 27, 2020·Molecular Genetics & Genomic Medicine·Francesca CucinottaAntonio M Persico
May 16, 2020·Journal of Autism and Developmental Disorders·Einat Waizbard-BartovDavid G Amaral
May 23, 2019·Autism Research : Official Journal of the International Society for Autism Research·Gil ZukermanEster Ben-Itzchak
Nov 18, 2020·Journal of Autism and Developmental Disorders·David MasonFrancesca Happé
Jul 10, 2018·Scandinavian Journal of Child and Adolescent Psychiatry and Psychology·Sigrídur Lóa JónsdóttirJón Fridrik Sigurdsson
Jan 22, 2021·Journal of Autism and Developmental Disorders·Patricia Howlin
Apr 27, 2021·The American Journal of Psychiatry·Lucy RiglinAnita Thapar
Jun 10, 2021·Revista brasileira de enfermagem·Gisele WeissheimerCibelly Aliny Siqueira Lima Freitas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Climacteric : the Journal of the International Menopause Society
E Jenabi, Jalal Poorolajal
American Journal of Epidemiology
Cristian M DogaruClaudia E Kuehni
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Shanliang ZhongJianhua Zhao
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Louise EmilssonJonas F Ludvigsson
© 2022 Meta ULC. All rights reserved