A systematic review and meta-analysis of the association between the apolipoprotein E genotype and delirium

Psychiatric Genetics
Dimitrios AdamisGeraldine McCarthy

Abstract

The role of apolipoprotein E (APOE) in Alzheimer's disease and other dementias has been investigated intensively. However, the relationship between APOE and delirium has only recently been explored in studies that have included relatively small samples. A meta-analysis of the published pooled data is timely to explore the relationship between APOE and delirium and to inform further research in this topic. PubMed, EBSCOhost, Google Scholar, Scopus, all EBM Reviews (OVID) and the Cochrane Database of Systematic Reviews were searched with relevant keywords and from the references of relevant papers. Ten papers were found that examined the relationship between APOE and delirium. Data were extracted from eight of them and pooled for meta-analysis using random effects with R software. Data from 1762 participants, of whom 479 (27.2%) were diagnosed with delirium, showed low heterogeneity (Q=13.11, d.f.=7, P=0.07; I=44.86%). The possession of the APOE ε4 allele has a small (log odds ratio: 0.18, 95% confidence interval: 0.23-0.59), nonsignificant (P=0.38) effect on the presence of delirium. No publication bias was identified. The metapower of the pooled data was low (α=0.05, power=0.65). On analysing the studies to date, it seems that ...Continue Reading

References

Jan 1, 1996·Annual Review of Neuroscience·W J Strittmatter, A D Roses
Jul 1, 1997·Neurology·M M MesulamS Weintraub
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Jan 26, 2006·Archives of Gerontology and Geriatrics·Dimitrios AdamisAlastair J D Macdonald
Jan 2, 2007·Critical Care Medicine·Yoanna Skrobik
Jan 5, 2007·International Journal of Geriatric Psychiatry·Dimitrios AdamisAlastair J D Macdonald
Jul 4, 2007·American Journal of Alzheimer's Disease and Other Dementias·Georgios I TagarakisAndreas Papassotiropoulos
Aug 31, 2007·Psychiatric Genetics·Barbara C van MunsterAeilko H Zwinderman
Jul 11, 2008·International Journal of Geriatric Psychiatry·Antoinette E ZehnderRené Spiegel
Feb 17, 2009·International Review of Psychiatry·Alasdair M J MacLullichDavid J Meagher
Nov 17, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Barbara C van MunsterSophia E J A de Rooij
May 18, 2010·Archives of Gerontology and Geriatrics·Dimitrios AdamisFinbarr C Martin
Jan 12, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory L BrysonHoward Nathan
Aug 24, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·A W OldenbeuvingG Roks
Jan 3, 2014·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Sheila A AlexanderYvette P Conley
Jul 26, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jennilee DavidsonWilliam G Bendena
Aug 19, 2014·International Journal of Geriatric Psychiatry·Sandra Quintino-SantosErico Castro-Costa
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein

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Citations

Dec 13, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Diego A ForeroJuan E Franco-Restrepo
Apr 16, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ping WangNiccolò Terrando
Sep 5, 2017·Dementia and Geriatric Cognitive Disorders Extra·Gideon A CaplanAnne Poljak
Nov 14, 2020·Nature Reviews. Disease Primers·Jo Ellen WilsonE Wesley Ely
Mar 30, 2021·European Archives of Psychiatry and Clinical Neuroscience·Esteban SepulvedaElisabet Vilella
May 14, 2021·Neuropsychiatric Disease and Treatment·Anita Nitchingham, Gideon A Caplan
Oct 13, 2021·NPJ Parkinson's Disease·Samantha GreenAngus D Macleod

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Software Mentioned

Scopus
R
metafor
Google Scholar

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