A systematic review and meta-analysis of the impact of mineralocorticoid receptor antagonists on glucose homeostasis

Medicine
Sandra KorolSimon de Denus

Abstract

Spironolactone, a nonselective mineralocorticoid receptor antagonist (MRA), may have a deleterious effect on glycemia. The objective of this review was to assess current knowledge on MRAs' influence (spironolactone, eplerenone, and canrenone) on glucose homeostasis and the risk of diabetes. A systematic review was conducted using the Medline database on articles published from 1946 to January 2017 that studied the effects of MRAs on any glucose-related endpoints, without any restrictions regarding the participants' characteristics.Study design, patient population, dose and duration of intervention, and the quantitative results on glycemic markers were extracted, interpreted for result synthesis, and evaluated for sources of bias. From the articles included in the qualitative analysis, a select number were used in a meta-analysis on studies having measured glycated hemoglobin (HbA1c) or risk of diabetes. Seventy-two articles were selected from the Medline database and references of articles. Results on spironolactone were heterogeneous, but seemed to be disease-specific. A potential negative effect on glucose regulation was mainly observed in heart failure and diabetes trials, while a neutral or positive effect was detected in d...Continue Reading

References

Jan 1, 1979·Clinical Pharmacology and Therapeutics·G Schrijver, M H Weinberger
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J N CloreC O Watlington
Oct 1, 1987·The American Journal of Cardiology·X JeunemaitreJ Menard
Apr 1, 1984·Archives of Internal Medicine·R P Ames, P B Peacock
Apr 2, 2003·The New England Journal of Medicine·Bertram PittUNKNOWN Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Aug 17, 2004·The Journal of Clinical Hypertension·Ari Mosenkis, Raymond R Townsend
Apr 30, 2005·The Journal of Clinical Hypertension·L Michael Prisant, Edward Chin
Dec 1, 2005·Kidney International·Katrine Jordan SchjoedtHans-Henrik Parving
Jul 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Cristiana CatenaLeonardo A Sechi
Sep 19, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Fabian Hammer, Paul M Stewart
Oct 21, 2006·Journal of Hypertension·Anton H van den MeirackerFrans Boomsma
Nov 10, 2006·Journal of the American Society of Nephrology : JASN·Janaka KarallieddeUNKNOWN Rosiglitazone Fluid Retention Study Group
Feb 21, 2007·Hypertension·Neil ChapmanUNKNOWN Anglo-Scandinavian Cardiac Outcomes Trial Investigators
May 10, 2007·The Journal of Clinical Endocrinology and Metabolism·Hylton V JoffeGail K Adler
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Murray EpsteinBruce Beckerman
Sep 22, 2007·Journal of Hypertension·Lorena M MossoCarlos E Fardella
Dec 20, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Michael B DavidsonElias S Siraj
Jan 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Dileep V MenonWanpen Vongpatanasin
Feb 7, 2009·Diabetes Care·David PreissUNKNOWN Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity Investigators
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·Panagiotis AnagnostisDimitri P Mikhailidis
May 30, 2009·Journal of Cardiac Failure·Ewa A JankowskaPiotr Ponikowski
Jul 23, 2009·Journal of Medical Virology·Yasuji AraseTetsuro Kobayashi
Aug 6, 2009·Archives of Gynecology and Obstetrics·Levent KebapcilarIsmail Sari
Oct 22, 2009·British Journal of Clinical Pharmacology·Manouchehr NakhjavaniParvin Pasalar

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Citations

May 22, 2019·American Journal of Physiology. Endocrinology and Metabolism·Elizabeth T NguyenMatia B Solomon
Nov 2, 2019·The Journal of Clinical Endocrinology and Metabolism·Anna P Ziganshina, Aidar R Gosmanov
Nov 2, 2019·The Journal of Clinical Endocrinology and Metabolism·Judith GerardsMarcus Quinkler
Apr 4, 2020·Diabetes, Obesity & Metabolism·Javed ButlerJulio Rosenstock
Mar 4, 2019·Current Hypertension Reports·Antonis A ManolisAntonis S Manolis

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Software Mentioned

EPLE
R Project for Computing
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SPIRO

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