A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran

Epidemiology and Health
Masoud Foroutan-RadElham Yousefi

Abstract

Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran. We searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied. A total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals. The current study revealed a high prevalence o...Continue Reading

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Citations

Apr 11, 2019·PLoS Neglected Tropical Diseases·Tooran Nayeri ChegeniAhmad Daryani
May 18, 2019·Epidemiology and Health·Shahabeddin SarviAhmad Daryani
Aug 17, 2018·Clinical and Experimental Vaccine Research·Masoud ForoutanFatemeh Ghaffarifar
Jan 30, 2020·Frontiers in Cellular and Infection Microbiology·Fabiana NakashimaLuiz Carlos de Mattos
Feb 19, 2019·Clinical and Experimental Vaccine Research·Masoud ForoutanOgholniaz Jorjani
Dec 13, 2018·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Shahrzad SoltaniMehdi Sagha Kahvaz
Jun 14, 2020·Acta Parasitologica·Farshid SaadatPanagiotis Karanis
Oct 29, 2020·Journal of Family Medicine and Primary Care·Vahid RahmanianSaied Bokaie
Jun 15, 2021·Interdisciplinary Perspectives on Infectious Diseases·Shahrzad SoltaniMasoud Foroutan
Jul 12, 2021·Microbial Pathogenesis·Ali TaghipourFatemeh Ghaffarifar

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Word
Google Scholar
ProQuest

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