A systematic review and meta-analysis of the diagnostic accuracy of biparametric prostate MRI for prostate cancer in men at risk.

Prostate Cancer and Prostatic Diseases
E J BassH U Ahmed

Abstract

Multiparametric magnetic resonance imaging (mpMRI), the use of three multiple imaging sequences, typically T2-weighted, diffusion weighted (DWI) and dynamic contrast enhanced (DCE) images, has a high sensitivity and specificity for detecting significant cancer. Current guidance now recommends its use prior to biopsy. However, the impact of DCE is currently under debate regarding test accuracy. Biparametric MRI (bpMRI), using only T2 and DWI has been proposed as a viable alternative. We conducted a contemporary systematic review and meta-analysis to further examine the diagnostic performance of bpMRI in the diagnosis of any and clinically significant prostate cancer. A systematic review of the literature from 01/01/2017 to 06/07/2019 was performed by two independent reviewers using predefined search criteria. The index test was biparametric MRI and the reference standard whole-mount prostatectomy or prostate biopsy. Quality of included studies was assessed by the QUADAS-2 tool. Statistical analysis included pooled diagnostic performance (sensitivity; specificity; AUC), meta-regression of possible covariates and head-to-head comparisons of bpMRI and mpMRI where both were performed in the same study. Forty-four articles were inclu...Continue Reading

References

Jul 4, 2002·Journal of the National Cancer Institute·Ruth EtzioniEric J Feuer
Mar 18, 2005·Journal of Computer Assisted Tomography·Ryota ShimofusaHisao Ito
Jun 17, 2006·Journal of Computer Assisted Tomography·Pietro TorricelliRenato Romagnoli
Dec 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Akihiro TanimotoSachio Kuribayashi
Jul 25, 2007·AJR. American Journal of Roentgenology·Masoom A HaiderJohn Trachtenberg
Dec 1, 2007·Journal of Magnetic Resonance Imaging : JMRI·Kengo YoshimitsuHiroshi Honda
Mar 12, 2009·Journal of the National Cancer Institute·Gerrit DraismaHarry de Koning
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
May 15, 2012·La Radiologia medica·D RinaldiP Torricelli
Jan 8, 2013·Journal of Magnetic Resonance Imaging : JMRI·Yoshiko UenoSatoru Takahashi
Oct 9, 2013·Systematic Reviews·Mariska M G LeeflangPetra Macaskill
Jan 24, 2014·AJR. American Journal of Roentgenology·Maarten de RooijMaroeska M Rovers
Mar 21, 2015·AJR. American Journal of Roentgenology·Cher Heng TanVikas Kundra
Oct 3, 2015·European Urology·Jeffrey C WeinrebSadna Verma
Sep 2, 2016·Acta Radiologica Open·Karen Cecilie Duus ThestrupHenrik S Thomsen
Nov 20, 2016·Clinical Genitourinary Cancer·Thaís Caldara MussiRonaldo Hueb Baroni
Mar 7, 2018·JAMA : the Journal of the American Medical Association·Richard M MartinUNKNOWN CAP Trial Group

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Citations

Mar 19, 2021·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Tobias FranielUNKNOWN Vorstand des Berufsverbandes der Deutschen Radiologen (BDR)
May 19, 2021·European Urology Oncology·Anwar R PadhaniJelle O Barentsz
Jul 9, 2021·The New England Journal of Medicine·Martin EklundUNKNOWN STHLM3 consortium
Aug 9, 2021·European Urology Oncology·Hendrik Van PoppelMonique J Roobol

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