A systematic review and meta-analysis of randomized controlled trials on the effectiveness of cervical ripening with misoprostol administration before hysteroscopy

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Zhihong ZhuoXingzhi Jiang

Abstract

Misoprostol is an effective cervical ripening agent. To determine the effect of misoprostol on cervical ripening before hysteroscopy. Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched for pertinent studies published before November 2014, using the search terms "hysteroscopy," "ripening," and "misoprostol." Randomized controlled trials published in English were included that compared the effects of misoprostol versus placebo on cervical dilatation before diagnostic or operative hysteroscopy. Random-effects models were used to calculate odds ratios or mean differences (MDs) with 95% confidence intervals (CIs). The analysis included 32 trials. Misoprostol had significant effects on the need for further cervical dilatation (odds ratio 0.29, 95% CI 0.17-0.50), the cervical width (MD 1.53, 95% CI 0.92-2.13), and the time taken for cervical dilatation (MD -0.35, 95% CI -0.50 to -0.20). Corresponding observations were made in the subgroup of premenopausal women, but not in the subgroup of postmenopausal women. Adverse effects were significantly more common with misoprostol than with placebo (risk difference 0.07, 95% CI 0.01-0.12). Misoprostol had a significant effect on cervical ripening before hyst...Continue Reading

Associated Clinical Trials

References

Jan 22, 1998·Human Reproduction·S W NgaiP C Ho
Sep 3, 1999·Obstetrics and Gynecology·S Preutthipan, Y Herabutya
Jul 26, 2000·Obstetrics and Gynecology·F W JansenT C Trimbos-Kemper
Jun 27, 2001·Human Reproduction·S W NgaiP C Ho
May 17, 2002·American Journal of Obstetrics and Gynecology·Jackie A ThomasRory C Windrim
Jun 18, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·T M FungL C Ho
Oct 22, 2003·The Journal of the American Association of Gynecologic Laparoscopists·Mazen BisharahTogas Tulandi
Aug 17, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·E BarcaiteR Nadisauskiene
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Krista M DaleC Michael White
Jun 14, 2006·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Joan M G Crane, Sarah Healey
Aug 24, 2007·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Sarah HealeyJoan M G Crane
Oct 27, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C FialaH von Hertzen
Feb 12, 2008·Journal of Minimally Invasive Gynecology·Aurélio Ribeiro da CostaJuliana Schettini
Jun 10, 2008·Journal of Minimally Invasive Gynecology·Emanuelle Pessa ValenteDanielle Veríssimo de Miranda
Oct 31, 2008·Journal of Minimally Invasive Gynecology·Guy WaddellPaul Bessette
Dec 17, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·K S OppegaardB-I Nesheim
Aug 24, 2010·Fertility and Sterility·Luis Humberto Sordia-HernándezArturo Morales

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Citations

Aug 21, 2016·Fertility and Sterility·Bijan W SalariSteven R Lindheim
Jan 11, 2017·Journal of Minimally Invasive Gynecology·Hadas Ganer HermanRon Sagiv
Feb 14, 2018·Menopause : the Journal of the North American Menopause Society·Fabiana Y NakanoLucia Helena Costa Paiva
Mar 26, 2019·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Zhihong ZhuoXingzhi Jiang
Jan 9, 2020·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Alice TassiAmbrogio P Londero
Nov 22, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Prathiba M De SilvaT Justin Clark
Oct 26, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Maria da Conceição Farias Souto MaiorAurélio Antônio Ribeiro da Costa

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