A Systematic Review and Meta-Analysis of Influenza A Virus Infection During Pregnancy Associated with an Increased Risk for Stillbirth and Low Birth Weight

Kidney & Blood Pressure Research
Jing HeYou-Peng Chen

Abstract

Impaired pregnancy outcomes, such as low birth weight are associated with increased disease risk in later life, however little is known about the impact of common infectious diseases during pregnancy on birth weight. The study had two aims: a) to investigate risk factors of influenza virus infection during pregnancy, and b) to analyze the impact of influenza virus infection on pregnancy outcome, especially birth weight. Prospective and retrospective observational studies found in PubMed, MEDLINE, Embase, Google Scholar, and WangFang database were included in this meta analysis. Data of included studies was extracted and analyzed by the RevMan software. Pregnant women with anemia (P=0.004, RR=1.46, 95% CI: 1.13-1.88), obesity (P<0.00001, RR=1.35, 95% CI: 1.25-1.46) and asthma (P<0.00001, RR=1.99, 95% CI: 1.67-2.37) had higher rates of influenza virus infection. Regarding birth outcomes, influenza A virus infection did not affect the likelihood for cesarean section. Mothers with influenza had a higher rate of stillbirth (P=0.04, RR=2.36, 95% CI: 1.05-5.31), and their offspring had low 5-minute APGR Scores (P=0.009, RR=1.39, 95% CI: 1.08-1.79). Furthermore, the rate for birth weight < 2500g (P=0.04, RR=1.71, 95% CI: 1.03-2.84) was...Continue Reading

Citations

Jul 13, 2020·BMC Infectious Diseases·Joon Young SongGeum Joon Cho
Dec 7, 2018·Epidemiology and Infection·I S RasmussenA-M Nybo Andersen
May 28, 2019·Frontiers in Immunology·Rebekah Honce, Stacey Schultz-Cherry
Nov 26, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Elizabeth M McClureRobert L Goldenberg
Jan 16, 2021·PloS One·Nicola VousdenUNKNOWN UKOSS Influenza Co-Investigators Group
Nov 30, 2020·Journal of Reproductive Immunology·Marcelo Borges CavalcanteJoanne Kwak-Kim
Dec 22, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Philippe BuchyJohn S Tam
Oct 17, 2020·Journal of Pregnancy·Reem S ChamseddineArash Rafii
Mar 2, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ruitong WangJue Liu
Apr 2, 2021·Chronobiology International·Takahiro UjiChisato Nagata
Apr 30, 2021·Journal of Global Infectious Diseases·Kavitha AbrahamMark C Steinhoff
May 1, 2021·International Journal of Environmental Research and Public Health·Sylvia Kirchengast, Beda Hartmann
Dec 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haiyang LiXuesong Yang

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