A Systematic Review and Meta-analysis of Antibiotic Treatment Duration for Bacteremia Due to Enterobacteriaceae

Antimicrobial Agents and Chemotherapy
Giannoula S TansarliEleftherios Mylonakis

Abstract

The duration of antibiotic therapy for bacteremia due to Enterobacteriaceae is not well defined. We sought to evaluate the clinical outcomes with shorter- versus longer-course treatment. We performed a systematic search of the PubMed and EMBASE databases through May 2018. Studies presenting comparative outcomes between patients receiving antibiotic treatment for ≤10 days ("short-course") and those treated for >10 days ("long-course") were considered eligible. Four retrospective cohort studies and one randomized controlled trial comprising 2,865 patients met the inclusion criteria. The short- and long-course antibiotic treatments did not differ in 30-day all-cause mortality (1,374 patients; risk ratio [RR] = 0.99; 95% confidence interval [CI], 0.69 to 1.43), 90-day all-cause mortality (1,750 patients; RR = 1.16; 95% CI, 0.81 to 1.66), clinical cure (1,080 patients; RR = 1.02; 95% CI, 0.96 to 1.08), or relapse at 90 days (1,750 patients; RR = 1.08; 95% CI, 0.69 to 1.67). In patients with bacteremia due to Enterobacteriaceae, the short- and long-course antibiotic treatments did not differ significantly in terms of clinical outcomes. Further well-designed studies are needed before treatment for 10 days or less is adopted in clinica...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Teresa M. Barbosa, Stuart B. Levy
Aug 28, 2002·Scandinavian Journal of Infectious Diseases·François-Xavier HanonHenrik Schønheyder
Aug 9, 2003·Journal of Clinical Microbiology·D J DiekemaG V Doern
Dec 31, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodger D MacArthurWilliam Barchuk
Sep 11, 2004·Journal of Clinical Epidemiology·Carl van WalravenGeorge A Wells
Nov 1, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mike Clarke
Jan 25, 2008·Pharmacoepidemiology and Drug Safety·Sharon B MeropolJoshua P Metlay
Jun 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leonard A MermelDavid K Warren
Jul 5, 2011·FEMS Microbiology Reviews·Rafael Cantón, María-Isabel Morosini
Dec 8, 2011·The Journal of Antimicrobial Chemotherapy·Marjolein P M HensgensEd J Kuijper
Nov 15, 2012·Critical Care : the Official Journal of the Critical Care Forum·Marin H KollefRebecca Redman
Mar 12, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Goto, M N Al-Hasan
Jan 15, 2014·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Thomas C HaveyNick Daneman
Sep 15, 2014·The Journal of Infection·Stig Lønberg NielsenCourt Pedersen
Oct 27, 2015·Critical Care Medicine·Nick DanemanUNKNOWN Canadian Critical Care Trials Group
Nov 5, 2016·International Journal of Antimicrobial Agents·Leila F KutobMajdi N Al-Hasan
Nov 3, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tristan T TimbrookKerry L LaPlante
Dec 29, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Shunsuke UnoNaoto Hosokawa
Dec 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Darunee ChotiprasitsakulUNKNOWN Antibacterial Resistance Leadership Group
Dec 29, 2017·International Journal of Antimicrobial Agents·Nicholas J MercuroMinkey Wungwattana
Jan 27, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M GiannellaP Viale
Feb 7, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A DoiK Iwata
Dec 12, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dafna YahavUNKNOWN Bacteremia Duration Study Group

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Citations

Jun 28, 2020·The Journal of Antimicrobial Chemotherapy·María Ruiz-RuigómezJosé María Aguado
Jul 16, 2021·Current Opinion in Infectious Diseases·Sergio ReyesDavid P Nicolau
Jul 16, 2021·Current Opinion in Infectious Diseases·María Ruiz-Ruigómez, Jose María Aguado

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