A Systematic Review and Meta-Analysis of Depression and Protein-Energy Wasting in Kidney Disease.

KI Reports
L Parker GreggS Susan Hedayati

Abstract

Depression comorbid with chronic disease may be mediated by inflammation. We sought to characterize relationships between inflammatory biomarkers and depressive symptoms in patients with chronic kidney disease and end-stage kidney disease. A systematic literature search was conducted by 2 authors up to March 19, 2019, for studies of patients with chronic kidney disease or end-stage kidney disease evaluating circulating inflammatory biomarkers associated with depression of chronic disease: albumin, C-reactive protein (CRP), high-sensitivity CRP, interleukin-6 (IL-6), tumor necrosis factor-α, and interleukin-1. Standardized mean differences in biomarkers between individuals with and without depression were computed and analyzed using mixed effects models. Correlations between biomarkers and the severity of depressive symptoms were computed. Thirty-four studies (5652 participants) compared biomarkers between depressed and nondepressed individuals. Individuals with depression had lower albumin levels (standardized mean difference, -0.37; 95% confidence interval [CI], -0.61 to -0.13), higher CRP levels (standardized mean difference, 0.76; 95% CI, 0.16-1.37), and higher IL-6 levels (standardized mean difference, 0.42; 95% CI, 0.21-0....Continue Reading

Citations

Jul 24, 2020·Current Opinion in Nephrology and Hypertension·L Parker Gregg, S Susan Hedayati
Apr 17, 2021·Clinical Journal of the American Society of Nephrology : CJASN·L Parker GreggS Susan Hedayati
May 9, 2021·Journal of Renal Care·Karen Nagalingam
Aug 28, 2021·International Journal of Environmental Research and Public Health·Yoshihiro AbikoAkira Toyofuku

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