A Systematic Review and Meta-Analysis of Interventions for Actinic Keratosis from Post-Marketing Surveillance Trials

Journal of Clinical Medicine
Theresa SteebMarkus V Heppt

Abstract

Multiple interventions are available for the treatment of actinic keratosis (AK) showing high efficacy in pivotal trials. However, data from post-marketing surveillance studies have received little attention until now. Here, we systematically investigate interventions for AK from post-marketing surveillance trials as a proxy for real-world efficacy and tolerability. A systematic literature search was conducted in Medline, Embase, and CENTRAL. Pertinent trial registers were hand-searched until 25 March 2020. Results were pooled using a random-effects model to calculate pooled proportions and relative risks (RR) or were described qualitatively. Eleven records with a total sample size of n = 4109 were included. Three of the studies had an active-controlled design, while seven were single-armed. Participant complete clearance ranged from 23.1% for diclofenac sodium 3% gel to 88.9% for ingenol mebutate 0.05% gel. The lesion-specific clearance rate for photodynamic therapy (PDT) was 74% (95% confidence interval (CI) 56-87%). The recurrence rate was significantly higher for diclofenac sodium 3% in comparison to imiquimod 5% cream (RR 1.10, 95% CI 1.02-1.1.8) and ranged from 10.6% for ingenol mebutate 0.015% gel to 23.5% for PDT. Few p...Continue Reading

References

Jun 6, 1992·BMJ : British Medical Journal·P C WallerM D Rawlins
Dec 22, 1999·Journal of the American Academy of Dermatology·S J Salasche
Dec 22, 1999·Journal of the American Academy of Dermatology·R L Moy
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Aug 28, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·T DirschkaC Garbe
Mar 16, 2012·The New England Journal of Medicine·Mark LebwohlBrian Berman
Aug 7, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Victor A Kiri
Apr 29, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Rolf-Markus SzeimiesAntje Melzer
Jan 18, 2017·The British Journal of Dermatology·D de BerkerB R Hughes
Mar 12, 2018·The British Journal of Dermatology·L SchmitzT Dirschka
Mar 12, 2019·The New England Journal of Medicine·Maud H E JansenKlara Mosterd
Apr 12, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·L SchmitzT Dirschka
Mar 5, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Markus V HepptClaus Garbe
Apr 7, 2020·The British Journal of Dermatology·T SteebC Berking

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Citations

Apr 20, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kristen KayAaron K Joseph

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Methods Mentioned

BETA
biopsies
dissect

Software Mentioned

Excel
Cochrane Risk of Bias Tool
Embase
Ovid
Evidence Project
R package “ meta ”

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