A Systematic Review and Meta-Analysis of Autoantibodies for Diagnosis and Prognosis in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

Frontiers in Neuroscience
Xiaoqian GuoXiangqi Tang

Abstract

Objectives: To review the available evidence on sensitivity and specificity of anti-NF155 antibody detection in diagnosing a specific subset of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and to calculate the frequencies of different autoantibodies to paranodal proteins. Background: Diagnosis of CIDP relies on clinical and neurophysiologic criteria and lacks useful diagnostic biomarkers. A subset of CIDP patients exhibit atypical clinical phenotypes and impaired response to conventional treatments. These patients were reported as having autoantibodies targeting paranodal protein neurofascin isoform 155 (NF155), contactin-1 (CNTN1), and contactin-associated protein-1 (CASPR1). Here, we conducted a meta-analysis to summarize evidence on the diagnostic and prognostic value of these autoantibodies, especially for anti-NF155 antibody. Methods: We searched the following electronic bibliographic databases: PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science. Eligible studies provided information to calculate the frequencies of anti-NF155 antibody and anti-CNTN1 antibody, the sensitivity and specificity of anti-NF155 antibody, and the incidence of improvement a...Continue Reading

References

Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Oct 27, 2012·Neurology·Judy King Man NgEdgar Meinl
Jan 3, 2013·Annals of Neurology·Luis QuerolIsabel Illa
Jul 2, 2014·Nature Reviews. Neurology·Norman Latov
Sep 30, 2014·Journal of Neuroimmunology·Weixing YanEmily K Mathey
Feb 20, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Kathrin DopplerClaudia Sommer
Mar 27, 2015·Brain : a Journal of Neurology·Yumako MiuraUNKNOWN CNTN1-CIDP Study Group
Sep 25, 2015·Neurology. Neuroimmunology and Neuroinflammation·Luis QuerolIsabel Illa
Oct 20, 2015·Annals of Clinical and Translational Neurology·Hidenori OgataJun-Ichi Kira
Feb 5, 2016·Neurology·Jérôme J DevauxNobuhiro Yuki
Jul 31, 2016·Brain : a Journal of Neurology·Kathrin DopplerClaudia Sommer
Jan 22, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Satoshi KuwabaraMasahiro Mori
Jun 3, 2017·Brain : a Journal of Neurology·Emilien DelmontJérôme J Devaux
Jun 12, 2017·Journal of Neuroimmunology·E K MatheyM C Kiernan
Jul 15, 2017·Nature Reviews. Neurology·Luis QuerolIsabel Illa
Dec 1, 2017·Neurology·Elisabeth BurnorEric Lancaster
Mar 15, 2019·The Journal of Clinical Investigation·Constance MansoJérôme J Devaux
May 12, 2019·Lancet Neurology·Carina BunschotenPieter A van Doorn
Jul 16, 2019·Current Opinion in Neurology·Elba Pascual-GoñiLuis Querol
Aug 28, 2019·Neurology. Neuroimmunology and Neuroinflammation·Helena StengelKathrin Doppler
Oct 28, 2019·Annals of Clinical and Translational Neurology·Hidenori OgataJun-Ichi Kira
Nov 7, 2019·Journal of Neuroimmunology·Xuli ZhangYuzhong Wang
Nov 23, 2019·Neurology. Neuroimmunology and Neuroinflammation·Andrea CorteseDiego Franciotta
Nov 27, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-M VallatJ Devaux
Jan 11, 2020·Muscle & Nerve·Suraj A MuleyMazen M Dimachkie
Jan 26, 2020·Journal of the Peripheral Nervous System : JPNS·Peter Y K Van den BerghDavid R Cornblath
Feb 23, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ludivine KoutonEmilien Delmont
Mar 29, 2020·Neurology and Therapy·Jeffrey A Allen
Aug 26, 2020·Journal of the Neurological Sciences·Jamila GodilChafic Karam

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Citations

Nov 4, 2021·Neurology. Neuroimmunology and Neuroinflammation·Lorena Martín-AguilarLuis Querol

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