A Systematic Review and Meta-Analysis on the Strength and Consistency of the Associations between Dupuytren Disease and Diabetes Mellitus, Liver Disease, and Epilepsy

Plastic and Reconstructive Surgery
Dieuwke C BroekstraEdwin R van den Heuvel

Abstract

The role of diabetes mellitus, liver disease, and epilepsy as risk factors for Dupuytren disease remains unclear. In this systematic review and meta-analysis, the strength and consistency of these associations were examined. The MEDLINE, EMBASE, and Web of Science databases were searched for articles reporting an association between Dupuytren disease and diabetes mellitus, liver disease, and epilepsy published before September 26, 2016. The frequencies of Dupuytren disease and diabetes mellitus, liver disease, and epilepsy were extracted, as was information on potential confounders. Generalized linear mixed models were applied to estimate pooled odds ratios, adjusted for confounders. Heterogeneity between studies was quantified using an intraclass correlation coefficient and was accounted for by a random effect for study. One thousand two hundred sixty unique studies were identified, of which 32 were used in the meta-analyses. An association between Dupuytren disease and diabetes mellitus was observed (OR, 3.06; 95 percent CI, 2.69 to 3.48, adjusted for age), which was stronger for type 1 diabetes mellitus than for type 2 diabetes mellitus but was not statistically significant (p = 0.24). An association between Dupuytren diseas...Continue Reading

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Citations

Aug 31, 2018·Annals of Plastic Surgery·Juan Rodolfo MellaVirginia Hung
Apr 2, 2019·EFORT Open Reviews·Rita GrazinaRui Lemos
May 19, 2019·BMC Musculoskeletal Disorders·Sanne MolenkampDieuwke C Broekstra
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Sep 25, 2020·Plastic and Reconstructive Surgery·Osaid H AlserDominic Furniss
Jan 10, 2021·Occupational Medicine·L MurínovἠLegáth
Oct 30, 2020·Journal of Orthopaedic Surgery and Research·Nader SalariAlireza Daneshkhah
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Oct 28, 2021·Deutsches Ärzteblatt International·Mike RuettermannPaul M N Werker

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