A systematic review and meta-analysis reveals pervasive effects of germline mitochondrial replacement on components of health

Human Reproduction Update
Ralph DoblerKlaus Reinhardt

Abstract

Mitochondrial replacement, a form of nuclear transfer, has been proposed as a germline therapy to prevent the transmission of mitochondrial diseases. Mitochondrial replacement therapy has been licensed for clinical application in the UK, and already carried out in other countries, but little is known about negative or unintended effects on the health of offspring born using this technique. Studies in invertebrate models have used techniques that achieve mitochondrial replacement to create offspring with novel combinations of mitochondrial and nuclear genotype. These have demonstrated that the creation of novel mitochondrial-nuclear interactions can lead to alterations in offspring characteristics, such as development rates, fertility and longevity. However, it is currently unclear whether such interactions could similarly affect the outcomes of vertebrate biomedical studies, which have sought to assess the efficacy of the replacement therapy. This systematic review addresses whether the effects of mitochondrial replacement on offspring characteristics differ in magnitude between biological (conducted on invertebrate models, with an ecological or evolutionary focus) and biomedical studies (conducted on vertebrate models, with a ...Continue Reading

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Citations

Mar 12, 2019·Human Reproduction Update·Adam Eyre-Walker
Jul 21, 2020·Cell Transplantation·Konstantinos SfakianoudisMara Simopoulou
Jun 3, 2020·Integrative and Comparative Biology·Erik N K IversonJustin C Havird
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Jan 28, 2021·Antioxidants·Pascale May-PanloupPascal Reynier
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Mar 2, 2021·Journal of Evolutionary Biology·Arunas RadzvilaviciusIain G Johnston
Aug 7, 2021·Frontiers in Genetics·Lin FuYang Yu

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