A Systematic Review and Recommendation for Reporting of Surrogate Endpoint Evaluation Using Meta-analyses

JNCI Cancer Spectrum
Wanling XieMeredith M Regan

Abstract

Meta-analysis of randomized controlled trials (RCTs) has been widely conducted for the evaluation of surrogate endpoints in oncology, but little attention has been given to the adequacy of reporting and interpretation. This review evaluated the reporting quality of published meta-analyses on surrogacy evaluation and developed recommendations for future reporting. We searched PubMed through August 2017 to identify studies that evaluated surrogate endpoints using the meta-analyses of RCTs in oncology. Both individual patient data (IPD) and aggregate data (AD) meta-analyses were included for the review. Eighty meta-analyses were identified: 22 used IPD and 58 used AD from multiple RCTs. We observed variability and reporting deficiencies in both IPD and AD meta-analyses, especially on reporting of trial selection, endpoint definition, study and patient characteristics for included RCTs, and important statistical methods and results. Based on these findings, we proposed a checklist and recommendations to improve completeness, consistency, and transparency of reports of meta-analytic surrogacy evaluation. We highlighted key aspects of the design and analysis of surrogate endpoints and presented explanations and rationale why these it...Continue Reading

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Citations

May 27, 2020·British Journal of Cancer·Jianrong ZhangJianxing He
Nov 25, 2020·Cancers·Everardo Delforge Saad, Marc Buyse
Mar 16, 2021·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Oriana CianiRod S Taylor
May 22, 2021·BMC Medical Informatics and Decision Making·Milan GeybelsRobert Bauer

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