A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder

Brain Imaging and Behavior
Zalina DezhinaDanai Dima

Abstract

Genetic factors account for up to 80% of the liability for schizophrenia (SCZ) and bipolar disorder (BD). Genome-wide association studies have successfully identified several genes associated with increased risk for both disorders. This has allowed researchers to model the aggregate effect of genes associated with disease status and create a polygenic risk score (PGRS) for each individual. The interest in imaging genetics using PGRS has grown in recent years, with several studies now published. We have conducted a systematic review to examine the effects of PGRS of SCZ, BD and cross psychiatric disorders on brain function and connectivity using fMRI data. Results indicate that the effect of genetic load for SCZ and BD on brain function affects task-related recruitment, with frontal areas having a more prominent role, independent of task. Additionally, the results suggest that the polygenic architecture of psychotic disorders is not regionally confined but impacts on the task-dependent recruitment of multiple brain regions. Future imaging genetics studies with large samples, especially population studies, would be uniquely informative in mapping the spatial distribution of the genetic risk to psychiatric disorders on brain proce...Continue Reading

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Citations

Mar 5, 2020·Molecular Psychiatry·Hengyi CaoTyrone D Cannon
Nov 20, 2018·Expert Review of Neurotherapeutics·Antonio L TeixeiraSudhakar Selvaraj
Feb 2, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Stavros I DimitriadisDavid E Linden
Mar 7, 2021·Journal of Personalized Medicine·Jinya SatoToshiaki Onitsuka
Jul 14, 2021·NeuroImage. Clinical·Zachary Adam YapleRongjun Yu
Dec 26, 2021·Clinical Pharmacology and Therapeutics·Danielle JohnsonBritt I Drögemöller

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Methods Mentioned

BETA
genotyping

Software Mentioned

Alphasim
ENIGMA
PGRS
CROSS

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