A systematic review of contralateral liver lobe hypertrophy after unilobar selective internal radiation therapy with Y90

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Jin-Yao TeoBrian K P Goh

Abstract

Curative liver resection is the treatment of choice for both primary and secondary liver malignancies. However, an inadequate future liver remnant (FLR) frequently precludes successful surgery. Portal vein embolization is the gold-standard modality for inducing hypertrophy of the FLR. In recent times, unilobar Yttrium-90 selective internal radiation therapy (SIRT) has been reported to induce hypertrophy of the contralateral, untreated liver lobe. The aim of this study is to review the current literature reporting on contralateral liver hypertrophy induced by unilobar SIRT. A systematic review of the English-language literature between 2000 and 2014 was performed using the search terms "Yttrium 90" OR "selective internal radiation therapy" OR "radioembolization" AND "hypertrophy". Seven studies, reporting on 312 patients, were included. Two hundred and eighty four patients (91.0%) received treatment to the right lobe. Two hundred and fifteen patients had hepatocellular carcinoma (HCC), 12 had intrahepatic cholangiocarcinoma, and 85 had liver metastases from mixed primaries. Y90 SIRT resulted in contralateral liver hypertrophy which ranged from 26 to 47% at 44 days-9 months. All studies were retrospective in nature, and heterogen...Continue Reading

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Citations

Dec 23, 2016·Medical Oncology·Anna Maria IerardiConstantinos T Sofocleous
Feb 16, 2018·Journal of Surgical Oncology·Christoph JustingerMichael R Schön
Mar 8, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Juan C SpinaRicardo Garcia Monaco
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Jun 10, 2020·Cardiovascular and Interventional Radiology·I KurilovaF M Gomez
Sep 16, 2020·The American Surgeon·Matthew DixonNiraj Gusani
Oct 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Beau Toskich, Tushar Patel
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Mar 13, 2021·World Journal of Hepatology·Matteo SerenariMatteo Cescon
Oct 28, 2018·Gastroenterology·Laura Kulik, Hashem B El-Serag

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