A systematic review of current immunological tests for the diagnosis of cattle brucellosis

Preventive Veterinary Medicine
Marie J DucrotoyI Moriyón

Abstract

Brucellosis is a worldwide extended zoonosis with a heavy economic and public health impact. Cattle, sheep and goats are infected by smooth Brucella abortus and Brucella melitensis, and represent a common source of the human disease. Brucellosis diagnosis in these animals is largely based on detection of a specific immunoresponse. We review here the immunological tests used for the diagnosis of cattle brucellosis. First, we discuss how the diagnostic sensitivity (DSe) and specificity (DSp), balance should be adjusted for brucellosis diagnosis, and the difficulties that brucellosis tests specifically present for the estimation of DSe/DSp in frequentistic (gold standard) and Bayesian analyses. Then, we present a systematic review (PubMed, GoogleScholar and CABdirect) of works (154 out of 991; years 1960-August 2017) identified (by title and Abstract content) as DSe and DSp studies of smooth lipopolysaccharide, O-polysaccharide-core, native hapten and protein diagnostic tests. We summarize data of gold standard studies (n = 23) complying with strict inclusion and exclusion criteria with regards to test methodology and definition of the animals studied (infected and S19 or RB51 vaccinated cattle, and Brucella-free cattle affected o...Continue Reading

Citations

May 7, 2020·Frontiers in Cellular and Infection Microbiology·Xin YangWenjing Wang
Oct 3, 2018·Tropical Medicine and Infectious Disease·Muhammad Zahoor Khan, Muhammad Zahoor
Oct 24, 2018·Microbiology and Immunology·Triveni KalleshamurthyRajeswari Shome
Feb 27, 2020·International Journal of Environmental Research and Public Health·Tariq JamilHeinrich Neubauer
Dec 24, 2020·The Veterinary Quarterly·Sandip Kumar KhuranaWanpen Chaicumpa
Apr 10, 2019·Comparative Immunology, Microbiology and Infectious Diseases·Mohsen TabasiSaeid Bouzari
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Muhammad Rashid KhanTariq Jamil
Sep 28, 2021·Frontiers in Veterinary Science·Dehui YinJinpeng Zhang
Dec 30, 2021·Transboundary and Emerging Diseases·Jose María BlascoIgnacio Moriyón

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