PMID: 11906840Mar 22, 2002Paper

A systematic review of cytogenetic studies conducted in human populations exposed to cadmium compounds

Mutation Research
Violaine VerougstraetePhilippe Hotz

Abstract

Exposure to cadmium fumes or dusts has been associated with an increased risk of lung cancer and the characterisation of the genotoxic potential of cadmium compounds is, among other possible mechanisms, an important element in the assessment of the carcinogenic hazard of the element. While there is some evidence that in experimental systems, cadmium compounds may exert genotoxic effects, the results of the epidemiological studies having examined cytogenetic endpoints in humans exposed to cadmium appear conflicting. Therefore, a systematic review was undertaken to assess whether a cytogenetic effect of cadmium exposure is supported by the studies with the strongest design. The relevant literature was identified through several databases and assessed with a check-list by two reviewers. Causes of heterogeneity between studies were looked for. Results were extracted and the strength of the evidence was evaluated with causality criteria. No studies met the criteria for being considered as very convincing. Several factors were identified that could explain contradictory findings (small sample size, selection bias, insufficient characterisation of exposure, lack of consideration of confounders) but their actual impact could not be con...Continue Reading

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Citations

Nov 28, 2012·Environmental Monitoring and Assessment·Huseyin SerencamMehmet Tufekci
Dec 4, 2003·Mutation Research·Michael P Waalkes
Oct 29, 2003·Toxicology·Michael WaisbergDetmar Beyersmann
Sep 16, 2003·Mutation Research·J PalusR Nilsson
Oct 20, 2005·Journal of Bioscience and Bioengineering·Se-Kwon KimEun-Ki Kim
Dec 1, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Frank ThévenodMarouan Abouhamed
Feb 13, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chunlian XiaoXue Zhou
Sep 28, 2010·Toxicology and Industrial Health·Khadiga S AbrahimMohamed M Hwaihy
Apr 6, 2004·Environmental and Molecular Mutagenesis·Mostapha RizkiRicardo Marcos
Sep 26, 2009·Toxicology Mechanisms and Methods·Ayla CelikDilek Eke
Jun 17, 2020·Archives of Toxicology·Andrea HartwigGerhard Eisenbrand

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