A systematic review of dydrogesterone for the treatment of recurrent miscarriage

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Howard Carp

Abstract

The objective of this systematic review was to assesses whether the orally acting progestagen, dydrogesterone lowers the incidence of subsequent miscarriage in women with recurrent miscarriage. A computerized search was performed in Medline, Embase and Ovid Medline for original reports with the product name "Duphaston" or "dydrogesterone" and limited to clinical human data. Thirteen reports of dydrogesterone treatment were identified. Two randomized trials and one non-randomized comparative trial were identified, including 509 women who fulfilled the criteria for meta-analysis. The number of subsequent miscarriages or continuing pregnancies per woman was compared in women receiving dydrogesterone compared to standard bed rest or placebo intervention. There was a 10.5% (29/275) miscarriage rate after dydrogesterone administration compared to 23.5% in control women (odds ratio for miscarriage 0.29 [confidence interval 0.13-0.65] and 13% absolute reduction in the miscarriage rate). The adverse and side effects were summarised in all 13 reports, and seemed to be minimal. Although all the predictive and confounding factors could not be controlled for, the results of this systematic review show a significant reduction of 29% in the o...Continue Reading

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Citations

Oct 22, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nasrin SaharkhizNafiseh Baheiraei
Feb 6, 2016·American Journal of Reproductive Immunology : AJRI·Arsène MekinianMarie Bornes
Mar 8, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nilesh TrivediVishal Vaidya
Mar 23, 2018·Climacteric : the Journal of the International Menopause Society·H J A Carp
Feb 23, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nancy Noyola-MartínezDavid Barrera
Aug 8, 2018·BMC Pregnancy and Childbirth·Hee Joong LeeBanghyun Lee
Sep 24, 2016·Hormone Molecular Biology and Clinical Investigation·Adolf E Schindler
Jan 23, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Fadi Ghazi MirzaClaire Pexman-Fieth
Nov 19, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M W P BarbosaW P Martins
Nov 28, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Natalia PodzolkovaClaire Pexman-Fieth
Apr 20, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Petra Stute
Apr 30, 2021·Lancet·Arri CoomarasamySiobhan Quenby
Aug 17, 2021·Frontiers in Immunology·Marie-Pierre PiccinniJulia Szekeres-Bartho

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