A systematic review of economic evaluations of advanced therapy medicinal products.

British Journal of Clinical Pharmacology
Huw Lloyd-Williams, Dyfrig A Hughes

Abstract

Advanced therapy medicinal products (ATMPs) represent a new category of medicinal products with a potential for transformative improvements in health outcomes but at exceptionally high prices. Routine adoption of ATMPs requires robust evidence of their cost-effectiveness. A systematic literature review of economic evaluations of ATMPs, including gene therapies, somatic cell therapies and tissue-engineered products, was conducted. Literature was searched using MedLine, Embase, PubMed, Cochrane Register, the NHS Economic Evaluation Database and the grey literature of health technology assessment organisations with search terms relating to ATMPs and economic evaluations. Titles were screened independently by 2 reviewers. Articles deemed to meet the inclusion criteria were screened independently on abstract, and full texts reviewed. Study findings were appraised critically. 4514 articles were identified, of which 23 met the inclusion criteria. There was some evidence supporting the cost-effectiveness of: chimeric antigen receptor T-cell therapy axicabtagene-ciloleucel (Yescarta), embryonic neural stem cells, tumour infiltrating lymphocytes, in vitro expanded myoblast, autologous chondrocyte implantation, ex vivo gene therapy (Strim...Continue Reading

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Citations

Jun 5, 2020·British Journal of Clinical Pharmacology·Andrew R ChampionDyfrig A Hughes
Jul 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maurizio MuracaEugenio Baraldi
Apr 27, 2021·British Journal of Clinical Pharmacology·Ana Hidalgo-Simon, Willem E Fibbe
May 27, 2021·Stem Cells International·Mehrdad Afarid, Fatemeh Sanie-Jahromi
Jun 10, 2021·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Elisabete Gonçalves
Sep 17, 2021·Frontiers in Bioengineering and Biotechnology·Dong-Sook KimSeungJin Bae
Sep 25, 2021·Npj Regenerative Medicine·Armin GarmanyAndre Terzic

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